Kras G12C– and G12D–driven lung cancers differ in oncogenic potency, immunogenicity, and relapse after Kras inhibition in mouse models

已完结 10 由 bobobo 发布于 2026/5/6 10:53:52

DOI:10.1126/scitranslmed.adq6647
作者：Hai-Cheng Huang,?Qing Deng,?Lei Guo,?Teresa Gorria,?Federica Pecci,?Daniella Yang,?Scott Rodig,?Luis De Las Casas,?Jill Hallin,?James G. Christensen,?Mark M. Awad,?Lin Xu,?Biagio Ricciuti,?Esra A. Akb
文献类型：期刊论文
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American Association for the Advancement of Science (AAAS)

Abstract：The development of allele-specific KRAS inhibitors underscores the importance of understanding the distinct tumor biology associated with common KRAS mutations, G12D and G12C, in genetically

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