Cardiac delivery of RNA therapeutics using antibody-oligonucleotide conjugates (AOCs) for treating genetic cardiomyopathies

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DOI:10.1016/j.cardfail.2024.08.020
作者：Georgios Karamanlidis,?Barbora Malecova,?Michael Cochran,?Philip R. Kovach,?Venkata R. Doppalapudi,?Hanhua Huang,?W. Michael Flanagan,?Sharon Paige,?Eileen Blasi
文献类型：期刊论文
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Elsevier

Abstract：BackgroundGenetic cardiomyopathies involving intrinsic abnormalities of the heart, are frequently driven by gain-of-function mutations, producing toxic proteins or mRNAs that contribute to t

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