Non-viral targeted integration of large DNA in primary human T cells independent of double-stranded DNA breaks.

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DOI:10.1038/s41551-026-01671-1
作者：Sen Fang, Na Tang, Yiyun Li, Shuyu Guo, Yangcan Chen, Xin Wang, Xueke Li, Yanping Hu, Jiawei Hao, Jun Wu, Qi Zhou, Haoyi Wang, Chenxin Wang,
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Nature

Abstract：Non-viral targeted integration of large DNA cargoes into human primary T cells typically requires the induction of genomic double-strand breaks (DSBs), a process associated with cytotoxicity

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