Asymmetric Synthesis of Small Molecule Inhibitors of IL-17A via Crystallization-Induced Diastereoselective Strecker Reaction

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DOI:10.1021/acs.orglett.5c01122
作者：Stephen N. Greszler, Gang Zhao, Michael A. Leitch, Ashley L. Ramos, Matthew P. Webster, Kristine E. Frank
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：Crystallization-induced asymmetric transformations can dramatically alter the product ratio from a reaction with inherently poor or undesired selectivity. Reported herein is a rare example o

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