Pevonedistat, a Nedd-8 Activating Enzyme Inhibitor, Upregulates NOXA to Increase Effectiveness of Azacitidine and Venetoclax in Preclinical Models of Acute Myelogenous Leukemia

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DOI:10.1182/blood-2019-123068
作者：Brianna N. Smith, Dan Cojocari, J. Purkal, M. Arrate, Haley E. Ramsey, J. Leverson, E. Boghaert, D. Phillips, M. Savona
文献类型：期刊论文
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American Society of Hematology (ASH)

Abstract：Introduction: Venetoclax (VEN), a selective BCL-2 inhibitor, has yielded exceptional response rates in patients with acute myeloid leukemia (AML). VEN binds BCL-2 to directly inhibit sequest

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