Route Design and Scale-Up of a Topoisomerase I Inhibitor Antibody–Drug Conjugate Payload

已完结 10 由龙行天下发布于 2026/4/16 10:25:43

DOI:10.1021/acs.oprd.4c00175
作者：William R. F. Goundry*,?Andrew M. Poulton,?Matthew Welham,?Kuangchu Dai,?Xiaohong Zhu,?Haijun Tao,?Canlin Tang,?Fanny Magne and Bertrand Cottineau,?
文献类型：期刊论文
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American Chemical Society (ACS)

Abstract：AstraZeneca is currently developing an antibody–drug conjugate for the treatment of cancer with a topoisomerase I inhibitor payload. The drug portion of the molecule is an analogue of the na

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