病毒辅助生物分子的定向进化。

IF 5.3 2区 材料科学 Q2 MATERIALS SCIENCE, MULTIDISCIPLINARY
Delilah Jewel , Quan Pham , Abhishek Chatterjee
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引用次数: 0

摘要

定向进化是一种强大的技术,它利用自然进化的原理来开发具有新功能的生物分子。然而,自然进化的缓慢步伐并不支持在实验室中快速产生新的生物分子功能的需求。病毒为设计快速实验室进化实验提供了一条独特的途径,因为它们天生就有能力比大多数活生物体更快地进化,这得益于较小的基因组大小,可以容忍高频率的突变,以及快速的复制率。这些特性提供了一个很好的机会,通过将各种生物分子的活性与合适病毒的复制联系起来,来进化各种生物分子。本文综述了病毒辅助设计生物分子定向进化在原核细胞和真核细胞中的应用进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Virus-assisted directed evolution of biomolecules

Directed evolution is a powerful technique that uses principles of natural evolution to enable the development of biomolecules with novel functions. However, the slow pace of natural evolution does not support the demand for rapidly generating new biomolecular functions in the laboratory. Viruses offer a unique path to design fast laboratory evolution experiments, owing to their innate ability to evolve much more rapidly than most living organisms, facilitated by a smaller genome size that tolerate a high frequency of mutations, as well as a fast rate of replication. These attributes offer a great opportunity to evolve various biomolecules by linking their activity to the replication of a suitable virus. This review highlights the recent advances in the application of virus-assisted directed evolution of designer biomolecules in both prokaryotic and eukaryotic cells.

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来源期刊
CiteScore
8.30
自引率
3.40%
发文量
1601
期刊介绍: ACS Applied Nano Materials is an interdisciplinary journal publishing original research covering all aspects of engineering, chemistry, physics and biology relevant to applications of nanomaterials. The journal is devoted to reports of new and original experimental and theoretical research of an applied nature that integrate knowledge in the areas of materials, engineering, physics, bioscience, and chemistry into important applications of nanomaterials.
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