黄体酮通过增强小鼠精子的超激活来提高体外受精的成功率。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-06-06 DOI:10.1262/jrd.2022-114

Risa Suzuki, Masakatsu Fujinoki

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引用次数: 0

摘要

黄体酮(P)增强精子过度活化，这是一种能化事件。过度激活与成功的体外受精(IVF)有关。在本研究中，我们检测了P对小鼠过度激活和体外受精的影响。P以剂量依赖性的方式增强精子的超激活，提高体外受精成功率。此外，P通过精子头部的膜孕酮受体影响精子的过度激活和体外受精。上述结果表明，磷对小鼠精子获能和受精具有调控作用。P的浓度在发情周期中发生变化，表明精子对输卵管环境作出反应，并随后使卵母细胞受精。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice.

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Progesterone increases the success of in vitro fertilization via enhanced sperm hyperactivation in mice.

Progesterone (P) enhances spermatozoal hyperactivation, a capacitation event. Hyperactivation is associated with successful in vitro fertilization (IVF). In this study, we examined the effects of P on hyperactivation and IVF in mice. P enhanced spermatozoal hyperactivation and increased IVF success rate in a dose-dependent manner. Moreover, P affected spermatozoal hyperactivation and IVF through the membrane progesterone receptor of the spermatozoal head. These results show that P regulates spermatozoal capacitation and fertilization in mice. The concentration of P changes during the estrous cycle, indicating that spermatozoa are capacitated in response to the oviductal environment and subsequently fertilize the oocyte.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.