东非野生黑猩猩的MHC-B多样性和呼吸系统疾病的迹象。

S R Phillips
{"title":"东非野生黑猩猩的MHC-B多样性和呼吸系统疾病的迹象。","authors":"S R Phillips","doi":"10.1101/2023.08.02.551731","DOIUrl":null,"url":null,"abstract":"<p><p>bioRxiv has withdrawn this preprint following a formal investigation by the University of New Mexico Office of Research Integrity and Compliance.</p>","PeriodicalId":72407,"journal":{"name":"bioRxiv : the preprint server for biology","volume":" ","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2025-02-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418158/pdf/","citationCount":"0","resultStr":"{\"title\":\"WITHDRAWN: <i>MHC-B</i> Diversity and Signs of Respiratory Illness in Wild, East African Chimpanzees ( <i>Pan troglodytes schweinfurthii</i> ).\",\"authors\":\"S R Phillips\",\"doi\":\"10.1101/2023.08.02.551731\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>bioRxiv has withdrawn this preprint following a formal investigation by the University of New Mexico Office of Research Integrity and Compliance.</p>\",\"PeriodicalId\":72407,\"journal\":{\"name\":\"bioRxiv : the preprint server for biology\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2025-02-26\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10418158/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"bioRxiv : the preprint server for biology\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1101/2023.08.02.551731\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"bioRxiv : the preprint server for biology","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1101/2023.08.02.551731","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0

摘要

生物内在和外在的许多特征导致了野生生境中免疫的个体间差异。脊椎动物主要组织相容性复合体(MHC)包括编码抗原呈递分子的基因,这些抗原呈递分子是高度可变的,这种变异通常预测对病原体感染的易感性/抗性和恢复。我比较了两个长期黑猩猩研究地点的MHC-B变异,乌干达的基巴莱国家公园和坦桑尼亚的贡贝国家公园。利用几十年来对这些黑猩猩的呼吸健康数据,我测试了与MHC位点多样性维持相关的假设,包括杂合子、发散等位基因和稀有等位基因优势假设,以及对类人猿MHC- b独特功能的预测。我发现,尽管Kibale黑猩猩和Gombe黑猩猩最近有共同的祖先,包括重叠的MHC-B等位基因库和相似的MHC-B表型组成,但两个研究地点的黑猩猩在呼吸症状的发生上存在差异,并且MHC-B多样性与呼吸疾病的症状有不同的关联。具有杂合子基因型和不同肽结合超型的基巴莱黑猩猩与具有相同超型或纯合子基因型的基巴莱黑猩猩相比,出现呼吸体征的频率较低,但在贡贝黑猩猩中没有发现这种关联。与具有其他表型的黑猩猩相比,具有特定MHC-B表型的贡贝黑猩猩比具有其他表型的黑猩猩更容易出现呼吸体征,但在Kanyawara没有观察到这一点。本研究强调了在不同传染病环境下,甚至在同一亚种的近亲遗传中,形成遗传和表型性状的局部适应,并强调了在野生物种中持续和同时跟踪宿主免疫基因和特定病原体的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
WITHDRAWN: MHC-B Diversity and Signs of Respiratory Illness in Wild, East African Chimpanzees ( Pan troglodytes schweinfurthii ).

bioRxiv has withdrawn this preprint following a formal investigation by the University of New Mexico Office of Research Integrity and Compliance.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
自引率
0.00%
发文量
0
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信