挥发性有机化合物在炎症性肠病中的诊断效用：系统回顾与元分析》。

IF 8.3 2区医学 Q1 GASTROENTEROLOGY & HEPATOLOGY

Journal of Crohns & Colitis Pub Date : 2024-02-26 DOI:10.1093/ecco-jcc/jjad132

Ashwin Krishnamoorthy, Subashini Chandrapalan, Marriam Ahmed, Ramesh P Arasaradnam

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引用次数: 0

摘要

背景：挥发性有机化合物有望成为溃疡性结肠炎和克罗恩病的潜在生物标志物。非侵入性生物标志物有助于早期诊断和治疗。在本研究中，我们回顾了有关炎症性肠病 VOC 诊断准确性的研究：方法：我们在 Pubmed 和 Scopus 数据库中进行了系统搜索，共审查了 16 项研究，并对 10 项研究进行了荟萃分析：对 696 例炎症性肠病[IBD]病例和 605 例对照病例进行的荟萃分析表明，总体灵敏度和特异度分别为 87%（95% 置信区间 [CI]，0.79 - 0.92）和 83%（95% 置信区间 [CI]，0.73 - 0.90）。曲线下面积[AUC]为 0.92：作为 IBD 的非侵入性生物标记物，VOC 的表现非常出色，未来还有很大的改进和研究空间。

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The Diagnostic Utility of Volatile Organic Compounds in Inflammatory Bowel Disease: A Systematic Review and Meta-Analysis.

Background: Volatile organic compounds [VOCs] show promise as potential biomarkers of for ulcerative colitis and Crohn's disease, two chronic, idiopathic, gastrointestinal disorders with diagnostic and management challenges. Non-invasive biomarkers aid early diagnosis and management. In this study we review studies of diagnostic accuracy of VOCs in inflammatory bowel disease.

Methods: A systematic search was carried out on the Pubmed and Scopus databases; with 16 studies reviewed and meta-analysis carried out on 10.

Results: Meta-analysis of 696 inflammatory bowel disease [IBD] cases against 605 controls revealed a pooled sensitivity and specificity of 87% (95% confidence interval [CI], 0.79 - 0.92) and 83% [95% CI, 0.73 - 0.90], respectively. Area under the curve [AUC] was 0.92.

Conclusion: VOCs perform very well as non-invasive biomarkers of IBD, with much scope for future improvement and research.

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来源期刊

Journal of Crohns & Colitis 医学-胃肠肝病学

CiteScore

15.50

自引率

7.50%

发文量

1048

审稿时长

1 months

期刊介绍： Journal of Crohns and Colitis is concerned with the dissemination of knowledge on clinical, basic science and innovative methods related to inflammatory bowel diseases. The journal publishes original articles, review papers, editorials, leading articles, viewpoints, case reports, innovative methods and letters to the editor.