Ryan A. P. Homes, Fiona Giddens, Ross S. Francis, Ruth E. Hubbard, Emily H. Gordon, Mark J. Midwinter
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The frailty index score indicated significant correlations with total vessel density (<i>p</i> < .0001, <i>r</i> = −.56), microvascular flow index (<i>p</i> = .004, <i>r</i> = −.43), portion of perfused vessels (<i>p</i> = .0004, <i>r</i> = −.52), heterogeneity index (<i>p</i> = .015, <i>r</i> = .32), and perfused vessel density (<i>p</i> < .0001, <i>r</i> = −.66). No correlation was shown between the frailty index and age (<i>p</i> = .08, <i>r</i> = .27).</p>\n </section>\n \n <section>\n \n <h3> Conclusions</h3>\n \n <p>There is a relationship between the frailty index and microcirculatory health in those attending a kidney transplant assessment clinic, that is not confounded by age. 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引用次数: 1
摘要
目的探讨肾移植评估门诊患者舌下微循环指标与衰弱指数的关系。方法采用侧流暗场视频显微镜(MicroScan, Micro Vision Medical, Amsterdam, Netherlands)对入选患者进行舌下微循环检查，并采用经验证的短表格进行访谈，对患者进行衰弱指数评分。结果共纳入44例患者，其中2例因微循环图像质量评分超过10分而被排除。衰弱指数评分与总血管密度呈显著相关(p <)。0001, r =−0.56)，微血管流动指数(p = 0.56)。004, r = - 0.43)，灌注血管部分(p =。0004, r =−.52)，异质性指数(p =。015, r = .32)，灌注血管密度(p <0001, r =−0.66)。虚弱指数与年龄无相关性(p =。08, r = .27)。结论肾移植评估门诊患者虚弱指数与微循环健康之间存在相关性，且不受年龄的影响。这些发现表明微循环受损可能是虚弱的潜在原因。
The sublingual microcirculation and frailty index in chronic kidney disease patients
Objective
To examine the relationship between sublingual microcirculatory measures and frailty index in those attending a kidney transplant assessment clinic.
Methods
Patients recruited had their sublingual microcirculation taken using sidestream dark field videomicroscopy (MicroScan, Micro Vision Medical, Amsterdam, the Netherlands) and their frailty index score using a validated short form via interview.
Results
A total of 44 patients were recruited with two being excluded due to microcirculatory image quality scores exceeding 10. The frailty index score indicated significant correlations with total vessel density (p < .0001, r = −.56), microvascular flow index (p = .004, r = −.43), portion of perfused vessels (p = .0004, r = −.52), heterogeneity index (p = .015, r = .32), and perfused vessel density (p < .0001, r = −.66). No correlation was shown between the frailty index and age (p = .08, r = .27).
Conclusions
There is a relationship between the frailty index and microcirculatory health in those attending a kidney transplant assessment clinic, that is not confounded by age. These findings suggest that the impaired microcirculation may be an underlying cause of frailty.
期刊介绍：
The journal features original contributions that are the result of investigations contributing significant new information relating to the vascular and lymphatic microcirculation addressed at the intact animal, organ, cellular, or molecular level. Papers describe applications of the methods of physiology, biophysics, bioengineering, genetics, cell biology, biochemistry, and molecular biology to problems in microcirculation.
Microcirculation also publishes state-of-the-art reviews that address frontier areas or new advances in technology in the fields of microcirculatory disease and function. Specific areas of interest include: Angiogenesis, growth and remodeling; Transport and exchange of gasses and solutes; Rheology and biorheology; Endothelial cell biology and metabolism; Interactions between endothelium, smooth muscle, parenchymal cells, leukocytes and platelets; Regulation of vasomotor tone; and Microvascular structures, imaging and morphometry. Papers also describe innovations in experimental techniques and instrumentation for studying all aspects of microcirculatory structure and function.
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