低强度体外冲击波治疗阴茎和周围神经再生的分子机制。

IF 1 Q4 UROLOGY & NEPHROLOGY
Dongyi Peng, Yan Tan, Amanda B Reed-Maldonado, Guiting Lin, Tom F Lue
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引用次数: 0

摘要

从长期发病、致残和经济成本的角度来看,对受损周围神经进行充分的功能修复是一个巨大的临床挑战。根治性前列腺切除术后的神经损伤是勃起功能障碍最常见的原因。近年来,低强度体外冲击波治疗被用于改善周围神经修复和再生的效果。研究表明,神经手术后应用低强度体外冲击波治疗可促进神经再生,改善功能预后,强调了低强度体外冲击波治疗诱导细胞活化和有丝分裂与神经营养因子增加、雪旺细胞活化和细胞信号活化有关的机制。我们在PubMed检索了与这些主题相关的体外和体内动物模型研究的文章,发现大量研究表明,应用低强度体外冲击波治疗可能是一种治疗神经损伤和其他与神经损伤相关疾病引起的勃起功能障碍的新方法。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Molecular Mechanism of Action of Low-Intensity Extracorporeal Shockwave Therapy for Regenerating Penile and Peripheral Nerves.

Sufficient functional repair of damaged peripheral nerves is a big clinical challenge in terms of long-lasting morbidity, disability, and economic costs. Nerve damage after radical prostatectomy is the most common cause of erectile dysfunction. In recent years, low-intensity extracorporeal shockwave therapy has been explored to improve the outcomes of peripheral nerve repair and regeneration. Research indicated that application of low-intensity extracorporeal shockwave therapy after nerve surgery promoted nerve regeneration and improved the functional outcomes, underlined the mechanisms related to increase of neurotrophic factors, Schwann cells activation, and cellular signaling activation for cell activation and mitosis induced by low-intensity extracorporeal shockwave therapy. We searched PubMed for articles related to research on these topics in both in vitro and in vivo animal models and found numerous studies suggesting that the application low-intensity extracorporeal shockwave therapy could be a novel treatment for erectile dysfunction induced by nerve injury and other disease related to nerve injury.

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来源期刊
Turkish journal of urology
Turkish journal of urology Medicine-Urology
CiteScore
2.10
自引率
0.00%
发文量
53
期刊介绍: The aim of the Turkish Journal of Urology is to contribute to the literature by publishing scientifically high-quality research articles as well as reviews, editorials, letters to the editor and case reports. The journal’s target audience includes, urology specialists, medical specialty fellows and other specialists and practitioners who are interested in the field of urology.
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