利什曼病未折叠蛋白反应途径研究进展。

IF 1.4 4区医学 Q4 IMMUNOLOGY

Parasite Immunology Pub Date : 2023-11-01 Epub Date: 2023-08-11 DOI:10.1111/pim.13009

Nimesha Madhushani Edirisinghe, Nuwani Harshamali Manamperi, Vishmi Samudika Wanasinghe, Nadira Karunaweera

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引用次数: 0

摘要

内质网（ER）生理状态的改变导致称为未折叠蛋白反应（UPR）或ER应激反应的特异性反应。UPR由三种传感器蛋白驱动，即：肌醇需要酶1、蛋白激酶RNA样ER激酶和激活转录因子6，以恢复ER稳态。致病性感染可启动UPR激活；一些病原体可以破坏普遍定期审议，以促进其生存和复制。包括利什曼原虫在内的许多细胞内病原体可以相互作用并劫持内质网以进行生存和复制，从而触发内质网应激，随后引发内质网应激反应。这篇综述旨在对利什曼原虫感染的ER应激反应进行全面综述。

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Unfolded protein response pathway in leishmaniasis: A review.

Alteration in the physiological state of the endoplasmic reticulum (ER) leads to the specific response known as unfolded protein response (UPR) or ER stress response. The UPR is driven by three sensor proteins, namely: Inositol-Requiring Enzyme 1, Protein Kinase RNA-like ER kinase and Activating Transcription Factor 6 to restore ER homeostasis. Pathogenic infection can initiate UPR activation; some pathogens can subvert the UPR to promote their survival and replication. Many intracellular pathogens, including Leishmania, can interact and hijack ER for their survival and replication, triggering ER stress and subsequently ER stress response. This review aims to provide a comprehensive overview of the ER stress response in infections with the Leishmania species.

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来源期刊

Parasite Immunology 医学-寄生虫学

CiteScore

4.70

自引率

4.50%

发文量

审稿时长

6-12 weeks

期刊介绍： Parasite Immunology is an international journal devoted to research on all aspects of parasite immunology in human and animal hosts. Emphasis has been placed on how hosts control parasites, and the immunopathological reactions which take place in the course of parasitic infections. The Journal welcomes original work on all parasites, particularly human parasitology, helminths, protozoa and ectoparasites.