{"title":"荧光素对糖尿病性黄斑水肿患者眼底荧光素血管造影后角膜内皮形态的影响。","authors":"Utku Limon, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Erdinç Bozkurt, Sinan Bulut, Betül Ilkay Sezgin Akçay","doi":"10.1080/15569527.2023.2215346","DOIUrl":null,"url":null,"abstract":"<p><strong>Purpose: </strong>To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME).</p><p><strong>Methods: </strong>In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial cell density (ECD), coefficient of variation of cell area (CV), average cell area (AVG), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were measured before FFA and at week 1 and month 1 after FFA were collected from patients' charts.</p><p><strong>Results: </strong>The study consisted of 48 patient's 48 eyes in Group-1 and 50 patient's 50 eyes in Group-2. In both groups, the mean ECD, CV, AVG, HEX, and CCT measurements at week 1 and month 1 after FFA did not differ statistically from the mean measurements before FFA (<i>p</i> > 0.05). The mean ECD measurements in Group-1 were higher than that in Group-2 and showed statistically significant differences among the groups (<i>p</i> < 0.01 for all). In the Pearson correlation analysis in Group-1, there was no statistically significant relationship between best-corrected visual acuity (BCVA) and (intraocular pressure) IOP values and ECD, AVG, CV, HEX, and CCT measurements (except central macular thickness [CMT] and HEX) before FFA, at week 1 and month 1 after FFA (<i>p</i> > 0.05). In Group-2 there was no statistically significant relationship between BCVA, IOP, and CMT measurements and ECD, AVG, CV, HEX, and CCT measurements before FFA, at week 1 and month 1 after FFA (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>There is no significant change in CEM after FFA in patients with NPDR and PDR with DME.</p>","PeriodicalId":11023,"journal":{"name":"Cutaneous and Ocular Toxicology","volume":"42 3","pages":"91-96"},"PeriodicalIF":1.6000,"publicationDate":"2023-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Effects of fluorescein on corneal endothelial morphology after fundus fluorescein angiography in patients with diabetic macular edema.\",\"authors\":\"Utku Limon, Işılay Özsoy Saygın, Tuğba Aydoğan Gezginaslan, Erdinç Bozkurt, Sinan Bulut, Betül Ilkay Sezgin Akçay\",\"doi\":\"10.1080/15569527.2023.2215346\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Purpose: </strong>To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME).</p><p><strong>Methods: </strong>In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial cell density (ECD), coefficient of variation of cell area (CV), average cell area (AVG), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were measured before FFA and at week 1 and month 1 after FFA were collected from patients' charts.</p><p><strong>Results: </strong>The study consisted of 48 patient's 48 eyes in Group-1 and 50 patient's 50 eyes in Group-2. In both groups, the mean ECD, CV, AVG, HEX, and CCT measurements at week 1 and month 1 after FFA did not differ statistically from the mean measurements before FFA (<i>p</i> > 0.05). The mean ECD measurements in Group-1 were higher than that in Group-2 and showed statistically significant differences among the groups (<i>p</i> < 0.01 for all). In the Pearson correlation analysis in Group-1, there was no statistically significant relationship between best-corrected visual acuity (BCVA) and (intraocular pressure) IOP values and ECD, AVG, CV, HEX, and CCT measurements (except central macular thickness [CMT] and HEX) before FFA, at week 1 and month 1 after FFA (<i>p</i> > 0.05). In Group-2 there was no statistically significant relationship between BCVA, IOP, and CMT measurements and ECD, AVG, CV, HEX, and CCT measurements before FFA, at week 1 and month 1 after FFA (<i>p</i> > 0.05).</p><p><strong>Conclusions: </strong>There is no significant change in CEM after FFA in patients with NPDR and PDR with DME.</p>\",\"PeriodicalId\":11023,\"journal\":{\"name\":\"Cutaneous and Ocular Toxicology\",\"volume\":\"42 3\",\"pages\":\"91-96\"},\"PeriodicalIF\":1.6000,\"publicationDate\":\"2023-09-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Cutaneous and Ocular Toxicology\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/15569527.2023.2215346\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"OPHTHALMOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cutaneous and Ocular Toxicology","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/15569527.2023.2215346","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"OPHTHALMOLOGY","Score":null,"Total":0}
引用次数: 0
摘要
目的:探讨荧光素对糖尿病性黄斑水肿(DME)患者眼底荧光素血管造影(FFA)后角膜内皮形态(CEM)的影响。方法:将患者分为非增殖性糖尿病视网膜病变(1组，NPDR)和增殖性糖尿病视网膜病变(2组，PDR)两组。CEM特性包括内皮细胞密度(ECD)、细胞面积变异系数(CV)、平均细胞面积(AVG)、六边形细胞百分比(HEX)和角膜中央厚度(CCT)在FFA前和FFA后第1周和第1个月从患者的图表中收集。结果:1组48例48眼，2组50例50眼。两组患者FFA后第1周和第1个月的平均ECD、CV、AVG、HEX和CCT测量值与FFA前的平均值无统计学差异(p > 0.05)。组1平均ECD值高于组2，组间差异有统计学意义(p p > 0.05)。第2组患者FFA前、FFA后第1周、第1个月的BCVA、IOP、CMT与ECD、AVG、CV、HEX、CCT无统计学意义(p > 0.05)。结论:NPDR和PDR合并DME患者FFA后CEM无明显变化。
Effects of fluorescein on corneal endothelial morphology after fundus fluorescein angiography in patients with diabetic macular edema.
Purpose: To evaluate the effects of fluorescein dye on corneal endothelial morphology (CEM) after fundus fluorescein angiography (FFA) in patients with diabetic macular edema (DME).
Methods: In this retrospective study, patients were divided into two groups, nonproliferative diabetic retinopathy (Group-1, NPDR) and proliferative diabetic retinopathy (Group-2, PDR). CEM properties including endothelial cell density (ECD), coefficient of variation of cell area (CV), average cell area (AVG), percentage of hexagonal cells (HEX), and central corneal thickness (CCT) were measured before FFA and at week 1 and month 1 after FFA were collected from patients' charts.
Results: The study consisted of 48 patient's 48 eyes in Group-1 and 50 patient's 50 eyes in Group-2. In both groups, the mean ECD, CV, AVG, HEX, and CCT measurements at week 1 and month 1 after FFA did not differ statistically from the mean measurements before FFA (p > 0.05). The mean ECD measurements in Group-1 were higher than that in Group-2 and showed statistically significant differences among the groups (p < 0.01 for all). In the Pearson correlation analysis in Group-1, there was no statistically significant relationship between best-corrected visual acuity (BCVA) and (intraocular pressure) IOP values and ECD, AVG, CV, HEX, and CCT measurements (except central macular thickness [CMT] and HEX) before FFA, at week 1 and month 1 after FFA (p > 0.05). In Group-2 there was no statistically significant relationship between BCVA, IOP, and CMT measurements and ECD, AVG, CV, HEX, and CCT measurements before FFA, at week 1 and month 1 after FFA (p > 0.05).
Conclusions: There is no significant change in CEM after FFA in patients with NPDR and PDR with DME.
期刊介绍：
Cutaneous and Ocular Toxicology is an international, peer-reviewed journal that covers all types of harm to cutaneous and ocular systems. Areas of particular interest include pharmaceutical and medical products; consumer, personal care, and household products; and issues in environmental and occupational exposures.
In addition to original research papers, reviews and short communications are invited, as well as concise, relevant, and critical reviews of topics of contemporary significance.
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