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引用次数: 0
摘要
滤泡调节性 T（Tfr）细胞在免疫反应中发挥着各种作用，有助于对外来抗原特异性 B 细胞反应进行正向和负向调节、控制自身反应性抗体反应和自身免疫，以及 B 细胞类别转换为 IgE 和过敏的发生。对小鼠的研究发现，CXCR5+FoxP3+CD4+ Tfr 细胞的不同亚群可对免疫调节做出不同贡献。此外，最近对人类 Tfr 细胞的研究也揭示了类似的复杂性，即具有不同来源、免疫抑制和/或免疫刺激特性的各种滤泡 T 细胞亚群。在这篇综述中，我们将概述和比较目前在小鼠和人类中发现的 Tfr 亚群，并讨论它们的起源和抗原特异性，以及潜在的作用模式和对控制自身免疫和过敏反应的贡献。
Follicular regulatory T cell subsets in mice and humans: origins, antigen specificity and function.
Follicular regulatory T (Tfr) cells play various roles in immune responses, contributing to both positive and negative regulation of foreign antigen-specific B cell responses, control over autoreactive antibody responses and autoimmunity, and B cell class-switching to IgE and allergy development. Studies conducted on mice uncovered various subsets of CXCR5+FoxP3+CD4+ Tfr cells that could differently contribute to immune regulation. Moreover, recent studies of human Tfr cells revealed similar complexity with various subsets of follicular T cells of different origins and immunosuppressive and/or immunostimulatory characteristics. In this review we will overview and compare Tfr subsets currently identified in mice and humans and will discuss their origins and antigen specificity, as well as potential modes of action and contribution to the control of the autoimmune and allergic reactions.
期刊介绍：
International Immunology is an online only (from Jan 2018) journal that publishes basic research and clinical studies from all areas of immunology and includes research conducted in laboratories throughout the world.
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