合并Cu(I)和Cu(II)光催化:用于顺序Cu(II)/Cu(I)催化乙烯烯氧allylation的多功能氧卤化方案的开发

IF 3.3 Q2 CHEMISTRY, MULTIDISCIPLINARY
Tirtha Mandal, Narenderreddy Katta, Hendrik Paps and Oliver Reiser*, 
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引用次数: 2

摘要

通过Cu(II)/Cu(I)-催化循环的合并,开发了一种通过α-卤代酮进行乙烯基芳烃氧烯丙基化的顺序光催化策略。最初的Cu(II)-光催化氧卤化利用配体到金属的电荷转移(LMCT),利用空气作为末端氧化剂从酰基卤化物产生卤化物自由基,可用于药物和农用化学品的后期改性。通过这种方式获得的α-溴酮酮随后可以进行一锅Cu(I)-光催化烯丙基化。这种顺序光催化以高度区域和化学选择性的方式进行,与苯乙烯的电子性质无关。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Merging Cu(I) and Cu(II) Photocatalysis: Development of a Versatile Oxohalogenation Protocol for the Sequential Cu(II)/Cu(I)-Catalyzed Oxoallylation of Vinylarenes

Merging Cu(I) and Cu(II) Photocatalysis: Development of a Versatile Oxohalogenation Protocol for the Sequential Cu(II)/Cu(I)-Catalyzed Oxoallylation of Vinylarenes

A sequential photocatalytic strategy is developed via the merger of Cu(II)/Cu(I)-catalytic cycles for the oxoallylation of vinyl arenes via α-haloketones. The initial Cu(II)-photocatalyzed oxohalogenation exploits ligand-to-metal charge transfer (LMCT) to generate halide radicals from acyl halides utilizing air as a terminal oxidant and can be employed for the late-stage modification of pharmaceuticals and agrochemicals. α-Bromoketones obtained this way can be subsequently subjected to a one-pot Cu(I)-photocatalyzed allylation. This sequential photocatalysis proceeds in a highly regio- and chemoselective fashion and is inconsequential to the electronic nature of styrenes.

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来源期刊
ACS Organic & Inorganic Au
ACS Organic & Inorganic Au 有机化学、无机化学-
CiteScore
4.10
自引率
0.00%
发文量
0
期刊介绍: ACS Organic & Inorganic Au is an open access journal that publishes original experimental and theoretical/computational studies on organic organometallic inorganic crystal growth and engineering and organic process chemistry. Short letters comprehensive articles reviews and perspectives are welcome on topics that include:Organic chemistry Organometallic chemistry Inorganic Chemistry and Organic Process Chemistry.
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