解开 mRNA 治疗的传递策略。

IF 2.5 4区医学 Q3 ONCOLOGY

Recent patents on anti-cancer drug discovery Pub Date : 2024-01-01 DOI:10.2174/1574892818666230607093231

Zhiyuan Luo, Yangchao Chen

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引用次数: 0

摘要

随着 mRNA 结构工程技术和递送平台的发展，mRNA 成为一种极具吸引力的治疗方式。mRNA 疗法应用于疫苗疗法、蛋白质替代疗法和基于嵌合抗原受体（CAR）T 细胞的疗法，在治疗癌症和罕见遗传病等多种疾病方面展现出巨大潜力，并取得了令人振奋的临床前和临床进展。在 mRNA 疗法中，有效的递送系统是其成功应用于疾病治疗的关键。这里主要介绍不同类型的 mRNA 递送策略，包括由脂质或聚合物材料制成的纳米颗粒、基于病毒的平台和基于外泌体的平台。

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Unlocking Delivery Strategies for mRNA Therapeutics.

mRNA emerged as an attractive therapy modality with the development of mRNA structure engineering techniques and delivery platforms. mRNA therapeutics, applied for vaccine therapy, protein replacement therapy, and chimeric antigen receptor (CAR) T cell-based therapy, has shown huge potential in treating a wide range of diseases, such as cancer and rare genetic diseases, with successful and exciting preclinical and clinical progress. In mRNA therapeutics, a potent delivery system is key to the success of its application for disease treatment. Herein, different types of mRNA delivery strategies, including nanoparticles produced from lipid or polymer materials, virus-based platforms, and exosome-based platforms, are mainly focused.

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来源期刊

Recent patents on anti-cancer drug discovery 医学-药学

CiteScore

4.50

自引率

7.10%

发文量

审稿时长

3 months

期刊介绍： Aims & Scope Recent Patents on Anti-Cancer Drug Discovery publishes review and research articles that reflect or deal with studies in relation to a patent, application of reported patents in a study, discussion of comparison of results regarding application of a given patent, etc., and also guest edited thematic issues on recent patents in the field of anti-cancer drug discovery e.g. on novel bioactive compounds, analogs, targets & predictive biomarkers & drug efficacy biomarkers. The journal also publishes book reviews of eBooks and books on anti-cancer drug discovery. A selection of important and recent patents on anti-cancer drug discovery is also included in the journal. The journal is essential reading for all researchers involved in anti-cancer drug design and discovery. The journal also covers recent research (where patents have been registered) in fast emerging therapeutic areas/targets & therapeutic agents related to anti-cancer drug discovery.