普萘洛尔阻断甲基苯丙胺在CD-1小鼠中的非条件和条件过度活动作用。

IF 1.6 4区心理学 Q3 BEHAVIORAL SCIENCES

Behavioural Pharmacology Pub Date : 2023-09-01 Epub Date: 2023-07-14 DOI:10.1097/FBP.0000000000000742

Anthony S Rauhut

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引用次数: 0

摘要

本实验检测了β-肾上腺素能受体系统在介导甲基苯丙胺的非条件（即药理学）和条件（即习得性）过度活跃作用中的作用。为此，小鼠接受了为期8天的调理程序，包括两种不同的、交替的疗程类型（室内和家笼日）。在试验室第1、3、5和7天，给小鼠（腹膜内）注射赋形剂（dH2 O）或普萘洛尔（16或32 mg/kg），并注射（皮下）30 分钟（min）后通过载体（生理盐水；未配对）或甲基苯丙胺（1.0 mg/kg；成对）。在家笼第2天、第4天、第6天和第8天，给小鼠（皮下）注射载体（生理盐水；配对）或甲基苯丙胺（1.0 mg/kg；未配对）关在家里的笼子里。条件性多动症的测试日为48 h在最后一个会议厅日之后。普萘洛尔剂量依赖性阻断甲基苯丙胺的非条件性和条件性多动作用，提示β-肾上腺素能系统在介导甲基苯丙胺这些作用中发挥作用。

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Propranolol blocks the unconditioned and conditioned hyperactive effects of methamphetamine in CD-1 mice.

The present experiment examined the contribution of the β-adrenergic receptor system in mediating the unconditioned (i.e. pharmacological) and conditioned (i.e. learned) hyperactive effects of methamphetamine. To this end, mice underwent an 8-day conditioning procedure involving two different, alternating session types (chamber and home-cage days). On chamber days (1, 3, 5, and 7), mice were injected (intraperitoneally) with vehicle (dH 2 O) or propranolol (16 or 32 mg/kg) and were injected (subcutaneously) 30 min (min) later by either vehicle (saline; unpaired) or methamphetamine (1.0 mg/kg; paired). On home-cage days (2, 4, 6, and 8), mice were injected (subcutaneously) with either vehicle (saline; paired) or methamphetamine (1.0 mg/kg; unpaired) in their home cages. The test day for conditioned hyperactivity occurred 48 h after the last chamber day. Propranolol dose-dependently blocked the unconditioned and conditioned hyperactive effects of methamphetamine, implicating a role for the β-adrenergic system in mediating these effects of methamphetamine.

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来源期刊

Behavioural Pharmacology 医学-行为科学

CiteScore

3.40

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Behavioural Pharmacology accepts original full and short research reports in diverse areas ranging from ethopharmacology to the pharmacology of schedule-controlled operant behaviour, provided that their primary focus is behavioural. Suitable topics include drug, chemical and hormonal effects on behaviour, the neurochemical mechanisms under-lying behaviour, and behavioural methods for the study of drug action. Both animal and human studies are welcome; however, studies reporting neurochemical data should have a predominantly behavioural focus, and human studies should not consist exclusively of clinical trials or case reports. Preference is given to studies that demonstrate and develop the potential of behavioural methods, and to papers reporting findings of direct relevance to clinical problems. Papers making a significant theoretical contribution are particularly welcome and, where possible and merited, space is made available for authors to explore fully the theoretical implications of their findings. Reviews of an area of the literature or at an appropriate stage in the development of an author’s own work are welcome. Commentaries in areas of current interest are also considered for publication, as are Reviews and Commentaries in areas outside behavioural pharmacology, but of importance and interest to behavioural pharmacologists. Behavioural Pharmacology publishes frequent Special Issues on current hot topics. The editors welcome correspondence about whether a paper in preparation might be suitable for inclusion in a Special Issue.