Ziyu Liu, Jingming Zhuang, Li Wei, Aiwen Lu, Jiangang Hou, Xiaoli Yang
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引用次数: 0
摘要
目的:回顾性分析不同治疗方法对原发性中枢神经系统淋巴瘤(PCNSL)患者认知功能、焦虑和抑郁的影响。方法:在Cochrane Library、CINAHL、PubMed、Web of Science、EMBASE、Sino Med、Wei Pu、Wan Fang、CNKI、Google Scholar等数据库中进行综合文献检索。搜索包括截至2023年6月20日发表的研究，重点关注新诊断为PCNSL的成年患者的认知功能、焦虑和抑郁。使用各种测量工具和量表来评估主要结果。我们进行了描述性系统综述，以整合文献并总结不同治疗方式对PCNSL患者认知功能、焦虑和抑郁的影响。本综述已在PROSPERO注册(CRD42022370250)。结果:共纳入43项研究。诱导化疗与大多数患者的认知功能改善、焦虑和抑郁减轻有关。全脑放疗(WBRT)被发现会导致认知障碍，特别是在执行、注意力、记忆和运动功能方面。低剂量WBRT、自体干细胞移植(ASCT)和血脑屏障破坏(BBBD)治疗不会导致显著的认知障碍。观察到焦虑和抑郁在长期内减少。结论:总体而言，PCNSL患者的认知功能、焦虑和抑郁可以通过适当的治疗得到改善。然而，与接受其他治疗方式的患者相比，接受WBRT治疗的患者认知能力下降的风险更高。因此，应特别关注接受WBRT的患者，并进行综合分析，以减少神经毒性并解决这些患者的早期认知问题。
A Systematic Review of Cognitive Function, Anxiety, and Depression in Patients With Newly Diagnosed Primary Central Nervous System Lymphoma.
Objective: To retrospectively analyze the effects of different treatments on cognitive functioning, anxiety, and depression in patients with primary central nervous system lymphoma (PCNSL).
Methods: A comprehensive literature search was conducted in multiple databases including the Cochrane Library, CINAHL, PubMed, Web of Science, EMBASE, Sino Med, Wei Pu, Wan Fang, CNKI, and Google Scholar. The search included studies published through June 20, 2023, focusing on cognitive function, anxiety, and depression in adult patients newly diagnosed with PCNSL. Various measurement tools and scales were used to assess the primary outcomes. Descriptive systematic reviews were conducted to integrate the literature and summarize the effects of different treatment modalities on cognitive functioning, anxiety, and depression in PCNSL patients. This review was registered with PROSPERO (CRD42022370250).
Results: A total of 43 studies were included. Induction chemotherapy was associated with improved cognitive function and reduced anxiety and depression in the majority of patients. Whole-brain radiotherapy (WBRT) was found to lead to cognitive impairment, particularly in executive, attention, memory, and motor function. Low-dose WBRT, autologous stem cell transplantation (ASCT), and blood-brain barrier disruption (BBBD) treatments did not result in significant cognitive impairment. Anxiety and depression were observed to decrease over the long term.
Conclusions: Overall, the cognitive functioning, anxiety, and depression of patients with PCNSL can be improved with appropriate treatments. However, patients treated with WBRT are at a higher risk of cognitive decline compared to those receiving other treatment modalities. Therefore, special attention should be given to patients undergoing WBRT, and a comprehensive analysis should be conducted to reduce neurotoxicity and address early cognitive problems in these patients.
期刊介绍：
Biological Research For Nursing (BRN) is a peer-reviewed quarterly journal that helps nurse researchers, educators, and practitioners integrate information from many basic disciplines; biology, physiology, chemistry, health policy, business, engineering, education, communication and the social sciences into nursing research, theory and clinical practice. This journal is a member of the Committee on Publication Ethics (COPE)
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