利培酮对斑马鱼胚胎毒性的评估。

IF 1.3 4区农林科学 Q2 VETERINARY SCIENCES

Comparative medicine Pub Date : 2023-08-27 Epub Date: 2023-08-03 DOI:10.30802/AALAS-CM-22-000123

Hirla Costa Silva Fukushima, Ricardo Lacava Bailone, Ricardo Carneiro Borra

{"title":"利培酮对斑马鱼胚胎毒性的评估。","authors":"Hirla Costa Silva Fukushima, Ricardo Lacava Bailone, Ricardo Carneiro Borra","doi":"10.30802/AALAS-CM-22-000123","DOIUrl":null,"url":null,"abstract":"Risperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goal of the current study was to examine the effects of risperidone in zebrafish embryos ( Danio rerio ) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.","PeriodicalId":10659,"journal":{"name":"Comparative medicine","volume":" ","pages":"260-266"},"PeriodicalIF":1.3000,"publicationDate":"2023-08-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702279/pdf/","citationCount":"0","resultStr":"{\"title\":\"Assessment of Risperidone Toxicity in Zebrafish (Danio rerio) Embryos.\",\"authors\":\"Hirla Costa Silva Fukushima, Ricardo Lacava Bailone, Ricardo Carneiro Borra\",\"doi\":\"10.30802/AALAS-CM-22-000123\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Risperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goal of the current study was to examine the effects of risperidone in zebrafish embryos ( Danio rerio ) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.\",\"PeriodicalId\":10659,\"journal\":{\"name\":\"Comparative medicine\",\"volume\":\" \",\"pages\":\"260-266\"},\"PeriodicalIF\":1.3000,\"publicationDate\":\"2023-08-27\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10702279/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Comparative medicine\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.30802/AALAS-CM-22-000123\",\"RegionNum\":4,\"RegionCategory\":\"农林科学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/8/3 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q2\",\"JCRName\":\"VETERINARY SCIENCES\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Comparative medicine","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.30802/AALAS-CM-22-000123","RegionNum":4,"RegionCategory":"农林科学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/8/3 0:00:00","PubModel":"Epub","JCR":"Q2","JCRName":"VETERINARY SCIENCES","Score":null,"Total":0}

引用次数: 0

摘要

利培酮是一种抗精神病药物，用于治疗自闭症和精神分裂症。本研究的目的是检查利培酮在斑马鱼胚胎（Danio rerio）中对生存、发育以及心脏和神经系统的影响。结果表明，浓度超过100μM与死亡、致畸作用、心脏毒性和神经毒性作用有关。这些发现支持斑马鱼在毒理学筛选研究中的实用性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

查看原文本刊更多论文

Assessment of Risperidone Toxicity in Zebrafish (Danio rerio) Embryos.

Risperidone is an antipsychotic medication used in the treatment of conditions like autism and schizophrenia. The goal of the current study was to examine the effects of risperidone in zebrafish embryos ( Danio rerio ) with regard to survival, development, and cardiac and neural systems. The results showed that concentrations above 100 μM were associated with deaths, teratogenic effects, and cardiotoxic and neurotoxic effects. The findings support the utility of zebrafish for toxicological screening studies.

求助全文

通过发布文献求助，成功后即可免费获取论文全文。去求助

来源期刊

Comparative medicine 医学-动物学

CiteScore

1.90

自引率

0.00%

发文量

审稿时长

6-12 weeks

期刊介绍： Comparative Medicine (CM), an international journal of comparative and experimental medicine, is the leading English-language publication in the field and is ranked by the Science Citation Index in the upper third of all scientific journals. The mission of CM is to disseminate high-quality, peer-reviewed information that expands biomedical knowledge and promotes human and animal health through the study of laboratory animal disease, animal models of disease, and basic biologic mechanisms related to disease in people and animals.