海洋来源的天然产品作为抗癌剂。

IF 1.9 4区医学 Q3 CHEMISTRY, MEDICINAL

Medicinal Chemistry Pub Date : 2023-01-01 DOI:10.2174/1573406419666221202144044

Nancy Saini, Ritika Sirohi, Anuradha A, Neetu Saini, Pankaj Wadhwa, Paranjeet Kaur, Vikas Sharma, Gurdeep Singh, Iqubal Singh, Sanjeev Kumar Sahu

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引用次数: 2

摘要

癌症是一种致命的人类疾病，由于生活方式、营养和全球变暖的变化，癌症的发病率正在上升。癌症的特点是不受控制的、紊乱的和不希望的细胞分裂。FDA批准的大约60%的抗癌药物是由天然成分制成的。在过去的十年中，为了更好地了解海洋生物提供的巨大化学多样性，人们进行了大量的努力，从而形成了一个有趣的“海洋管道”，用于潜在的抗癌临床和临床前治疗。本文综述了海产品作为抗癌药物的分子靶点，以及已报道的作用于不同靶点的不同化合物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Marine-derived Natural Products as Anticancer Agents.

Cancer is a deadly human disease on the rise due to changes in lifestyle, nutrition, and global warming. Cancer is characterized by uncontrolled, disordered, and undesired cell division. About 60% of cancer medicines approved by the FDA are made from natural ingredients. Intensive efforts over the last decade to better understand the vast chemical diversity provided by marine life have resulted in an intriguing "marine pipeline" of potential anticancer clinical and preclinical treatments. The molecular targets of marine products as anticancer drugs, as well as different reported compounds acting on distinct targets, are the topic of this review.

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来源期刊

Medicinal Chemistry 医学-医药化学

CiteScore

4.30

自引率

4.30%

发文量

109

审稿时长

12 months

期刊介绍： Aims & Scope Medicinal Chemistry a peer-reviewed journal, aims to cover all the latest outstanding developments in medicinal chemistry and rational drug design. The journal publishes original research, mini-review articles and guest edited thematic issues covering recent research and developments in the field. Articles are published rapidly by taking full advantage of Internet technology for both the submission and peer review of manuscripts. Medicinal Chemistry is an essential journal for all involved in drug design and discovery.