胃肠道癌症脊柱转移的流行病学和病理特征——一系列40例病例。

IF 1.2 4区 医学 Q4 DEVELOPMENTAL BIOLOGY
Ştefan Şelaru, Anca Sava, Dragoş Viorel Scripcariu, Claudia Florida Costea, Ana Maria Dumitrescu, Bogdan Costăchescu, Gabriela Florenţa Dumitrescu, Corina Ciupilan, Ruxandra Vatavu, Raluca Maria Haba, Vladimir Poroch, Lucia Corina Dima-Cozma, Valeriana Vornicu, Cristinel Ionel Stan
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引用次数: 1

摘要

癌症胃肠道(GI)的脊柱转移是罕见的,因此在文献中只有病例报告或小系列。我们工作的目的是确定罗马尼亚一家参考医院在九年内诊断和治疗的胃肠道癌脊柱转移的人口统计学方面、位置和组织病理学方面,并将获得的数据与最近的文献进行比较。这是一项关于胃肠道癌脊柱转移的回顾性病例系列研究,针对2013年1月至2021年12月期间在罗马尼亚伊阿希尼古拉·奥布鲁教授-博士急诊临床医院的三个神经外科诊所接受手术治疗的18岁以上患者,该医院是罗马尼亚一家关于脊柱转移手术治疗的三级医院。我们在研究中纳入了患者的人口统计学数据(年龄和性别)、临床数据(脊柱转移的位置)、放射学调查和病变的病理特征。关于免疫组织化学染色,使用以下抗体:抗细胞角蛋白(CK)7、抗CK20、抗CK19、抗尾型同源盒2(CDX2)、抗人表皮生长因子受体2(HER2)和抗Ki67。我们的系列包括40名成年患者(≥18岁),男女比例为3:1,有利于男性患者。所有患者的平均年龄为66.42岁。胃肠道癌症脊柱转移的主要部位来自胃肠道系统的所有节段:然而,最常见的是结肠直肠水平(40%),最少的是口腔水平(2.5%)。癌症脊柱转移最常见的部位主要是腰部(47.5%),最常的组织学类型是腺癌(57.5%),其次是肝细胞癌(27.5%)、胰腺导管癌(5%)和鳞状细胞癌(2.5%)。我们的研究结果具有重要的临床意义,因为它们表明,某些类型的胃肠道癌患者的某些亚群会导致脊柱某些区域的转移。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers - a series of 40 cases.

Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers - a series of 40 cases.

Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers - a series of 40 cases.

Epidemiological and pathological characteristics of spinal metastases from gastrointestinal cancers - a series of 40 cases.
Spinal metastases from gastrointestinal (GI) cancer are rare and as a result there are only case reports or small series in the literature. The aim of our work was to identify the demographic aspects, the location, and the histopathological aspects of spinal metastases from GI cancers diagnosed and treated in a reference Hospital in Romania over a period of nine years, and comparing the data obtained with those from the recent literature. This is a retrospective case series study on spinal metastases from GI cancers, developed in patients older than 18 years that were surgically treated between January 2013 and December 2021 within three Neurosurgery Clinics from Prof. Dr. Nicolae Oblu Emergency Clinical Hospital, Iaşi, Romania, which is a tertiary Hospital in Romania regarding the surgical treatment of spinal metastases. We included in our study the patient’s demographic data (age and gender), clinical data (location of spinal metastases), radiological investigations and pathological features of the lesions. Regarding the immunohistochemical stainings, the following antibodies were used: anti-cytokeratin (CK)7, anti-CK20, anti-CK19, anti-caudal-type homeobox 2 (CDX2), anti-human epidermal growth factor receptor 2 (HER2), and anti-Ki67. Our series included 40 adult patients (≥18 years old) with a male:female ratio of 3:1, in favor of male patients. The mean age of all patients was 66.42 years. The primary sites of spinal metastases from GI cancers were from all segments of the GI system: the most frequent, however, was from the colorectal level (40%) and the least from the oral cavity level (2.5%). The most common site of spinal metastases from GI cancer was predominantly lumbar region (47.5%), and the most frequent histological type was adenocarcinoma (57.5%), followed by hepatocellular carcinoma (27.5%), pancreatic ductal carcinoma (5%) and squamous cell carcinoma (2.5%). Our results have important clinical implications because they suggest that there are certain subsets of patients with certain types of GI cancers that cause metastases in certain regions of the spine.
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来源期刊
CiteScore
1.70
自引率
20.00%
发文量
221
审稿时长
3-8 weeks
期刊介绍: Romanian Journal of Morphology and Embryology (Rom J Morphol Embryol) publishes studies on all aspects of normal morphology and human comparative and experimental pathology. The Journal accepts only researches that utilize modern investigation methods (studies of anatomy, pathology, cytopathology, immunohistochemistry, histochemistry, immunology, morphometry, molecular and cellular biology, electronic microscopy, etc.).
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