蟾毒灵是一种减轻耐药性的药物。

IF 3.4 2区医学 Q2 PHARMACOLOGY & PHARMACY

Drug Metabolism Reviews Pub Date : 2023-08-01 DOI:10.1080/03602532.2023.2206065

Linxuan Miao, Ying Liu, Nasra Mohamoud Ali, Yan Dong, Bin Zhang, Xiaonan Cui

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引用次数: 2

摘要

肿瘤细胞的内在或获得性耐药是肿瘤化疗失败和肿瘤相关性死亡的主要原因。蟾毒灵(bufallin, BF)是从中药蟾蜍毒液(bufo gargarizans和bufo melanotictus Schneider的耳后腺体和表皮分泌物)中提取的主要活性单体成分。它是一种具有广谱抗癌作用的强心类固醇，在临床上已广泛用于治疗各种恶性肿瘤。药理学研究也发现BF具有逆转耐药的作用，为中药作为化学增敏剂在肿瘤治疗中的应用提供了新的视角。本文对已发表的减轻BF耐药的研究进行了广泛的检索和总结，并对其潜在的机制进行了综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Bufalin serves as a pharmaceutic that mitigates drug resistance.

Intrinsic or acquired drug resistance of tumor cells is the main cause of tumor chemotherapy failure and tumor-related death. Bufalin (BF) is the main active monomer component extracted from the Traditional Chinese Medicine Toad venom (secretions of glands behind the ears and epidermis of bufo gargarizans and Bufo Melanostictus Schneider). It is a cardiotonic steroid with broad-spectrum anti-cancer effects and has been widely used against various malignant tumors in clinical practice. Pharmacological studies also found that BF has the effect of reversing drug resistance, which provides a new perspective for the application of Traditional Chinese Medicine as a chemosensitizer in cancer therapy. This article provides an extensive search and summary of published research on mitigating drug resistance to BF and reviews its potential mechanisms.

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来源期刊

Drug Metabolism Reviews 医学-药学

CiteScore

11.10

自引率

1.70%

发文量

审稿时长

1 months

期刊介绍： Drug Metabolism Reviews consistently provides critically needed reviews of an impressive array of drug metabolism research-covering established, new, and potential drugs; environmentally toxic chemicals; absorption; metabolism and excretion; and enzymology of all living species. Additionally, the journal offers new hypotheses of interest to diverse groups of medical professionals including pharmacologists, toxicologists, chemists, microbiologists, pharmacokineticists, immunologists, mass spectroscopists, as well as enzymologists working in xenobiotic biotransformation.