尼可地尔对西酞普兰所致大鼠QT延长及心肌损伤的影响。

IF 1.6 4区 生物学 Q4 BIOTECHNOLOGY & APPLIED MICROBIOLOGY
Biotechnic & Histochemistry Pub Date : 2023-11-01 Epub Date: 2023-07-19 DOI:10.1080/10520295.2023.2233417
Gozde Akturk, Serap Cilaker Micili, Ozlem Gursoy Doruk, Nil Hocaoglu, Pinar Akan, Bekir Ugur Ergur, Samar Ahmed, Sule Kalkan
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引用次数: 0

摘要

西酞普兰是一种选择性血清素再摄取抑制剂(SSRI)抗抑郁药;在SSRI中表现出最大的心脏毒性作用。西酞普兰可引起药物诱导的长QT综合征(LQTS)和室性心律失常。我们研究了选择性线粒体KATP(mito-KATP)通道开放剂尼可地尔对西酞普兰引起的雄性大鼠LQTS和心肌损伤的保护作用。在一项初步研究中,我们确定延长QT间期的西酞普兰最小剂量为102 mg/kg腹膜内注射。在主要研究中,大鼠被随机分为五个实验组:未治疗的对照组、生理盐水+西酞普兰、尼可地尔+西酞仑、5-羟基癸酸盐(5-HD)+西酞泮、5-HD+尼可地尔+西酞普兰。评估了来自六只未经治疗的对照大鼠的血液和心脏组织样本的生化和组织学数据。评估心电图参数包括QRS持续时间、QT间期、校正QT间期(QTc)和心率(HR),并测量生化参数包括丙二醛、还原型谷胱甘肽、谷胱甘肽过氧化物酶、超氧化物歧化酶。我们还对心脏组织进行了组织形态学和免疫组织化学检查。西酞普兰显著延长QT QTc间期,显著增加组织形态学评分和凋亡细胞比例,但氧化剂和抗氧化剂参数没有差异。尼可地尔不能阻止西酞普兰诱导的QT QTc间期延长,氧化剂和抗氧化参数也没有显著变化;然而,它确实减少了西酞普兰引起的组织学损伤和细胞凋亡。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Effects of nicorandil on QT prolongation and myocardial damage caused by citalopram in rats.

Citalopram is a selective serotonin re-uptake inhibitor (SSRI) antidepressant; it exhibits the greatest cardiotoxic effect among SSRIs. Citalopram can cause drug-induced long QT syndrome (LQTS) and ventricular arrhythmias. We investigated the protective effect of nicorandil, a selective mitochondrial KATP (mito-KATP) channel opener, on LQTS and myocardial damage caused by citalopram in male rats. In a preliminary study, we determined that the minimum citalopram dose that prolonged the QT interval was 102 mg/kg injected intraperitoneally. For the main study, rats were divided randomly into five experimental groups: untreated control, normal saline + citalopram, nicorandil + citalopram, 5-hydroxydecanoate (5-HD) + citalopram, 5-HD + nicorandil + citalopram. Biochemical and histologic data from blood and heart tissue samples from six untreated control rats were evaluated. Electrocardiographic parameters including QRS duration, QT interval, corrected QT interval (QTc) and heart rate (HR) were assessed, and biochemical parameters including malondialdehyde, reduced glutathione, glutathione peroxidase, superoxide dismutase were measured. We also performed histomorphologic and immunohistochemical examination of heart tissue. Citalopram prolonged QT-QTc intervals significantly and increased significantly the histomorphologic score and proportion of apoptotic cells, but produced no differences in the oxidant and antioxidant parameters. Nicorandil did not prevent citalopram induced QT-QTc interval prolongation and produced no significant changes in oxidant and antioxidant parameters; however, it did reduce histologic damage and apoptosis caused by citalopram.

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来源期刊
Biotechnic & Histochemistry
Biotechnic & Histochemistry 生物-生物工程与应用微生物
CiteScore
3.40
自引率
6.20%
发文量
46
审稿时长
6-12 weeks
期刊介绍: Biotechnic & Histochemistry (formerly Stain technology) is the official publication of the Biological Stain Commission. The journal has been in continuous publication since 1926. Biotechnic & Histochemistry is an interdisciplinary journal that embraces all aspects of techniques for visualizing biological processes and entities in cells, tissues and organisms; papers that describe experimental work that employs such investigative methods are appropriate for publication as well. Papers concerning topics as diverse as applications of histochemistry, immunohistochemistry, in situ hybridization, cytochemical probes, autoradiography, light and electron microscopy, tissue culture, in vivo and in vitro studies, image analysis, cytogenetics, automation or computerization of investigative procedures and other investigative approaches are appropriate for publication regardless of their length. Letters to the Editor and review articles concerning topics of special and current interest also are welcome.
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