作为药物化学中潜在抗菌剂的生物活性查尔酮杂化物的最新进展。

IF 3.3 3区医学 Q2 CHEMISTRY, MEDICINAL

Mini reviews in medicinal chemistry Pub Date : 2024-01-01 DOI:10.2174/1389557523666230727102606

Anand Maurya, Alka Agrawal

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引用次数: 0

摘要

查耳酮是植物中产生的与类黄酮相关的芳香酮和烯酮。查耳酮具有广泛的生物活性，如抗肿瘤、镇静和抗菌活性。在本综述中，我们重点介绍了近期发表的有关查耳酮作为药物化学中一种独特抗菌框架的原创性研究文章。查耳酮在结构上具有多样性，可分为简单查耳酮和混合查耳酮，两者的核心药理结构都是 1,3-二芳基-2-丙烯-1-酮。查耳酮可以从天然资源中分离出来，也可以通过各种方法合成。本文还总结了它们的结构-活性关系、作用机制和专利清单。这篇综述文章概述了目前已发表的抗菌查尔酮混合物，并认为查尔酮衍生物在未来可能成为潜在的抗菌剂。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Recent Advancement in Bioactive Chalcone Hybrids as Potential Antimicrobial Agents in Medicinal Chemistry.

Chalcones are flavonoid-related aromatic ketones and enones generated from plants. The chalcones have a wide range of biological activities, such as anti-tumor, calming, and antimicrobial activities. In the present review, we have focused on the recently published original research articles on chalcones as a unique antibacterial framework in medicinal chemistry. Chalcones are structurally diverse moieties and can be split into simple and hybrid chalcones, with both having core pharmacophore 1,3-diaryl-2-propen-1-one. Chalcones are isolated from natural sources and also synthesized by using various methods. Their structure-activity relationship, mechanisms, and list of patents are also summarized in this paper. This review article outlines the currently published antimicrobial chalcone hybrids and suggests that chalcone derivatives may be potential antimicrobial agents in the future.

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来源期刊

Mini reviews in medicinal chemistry 医学-医药化学

CiteScore

7.80

自引率

0.00%

发文量

231

审稿时长

6 months

期刊介绍： The aim of Mini-Reviews in Medicinal Chemistry is to publish short reviews on the important recent developments in medicinal chemistry and allied disciplines. Mini-Reviews in Medicinal Chemistry covers all areas of medicinal chemistry including developments in rational drug design, synthetic chemistry, bioorganic chemistry, high-throughput screening, combinatorial chemistry, drug targets, and natural product research and structure-activity relationship studies. Mini-Reviews in Medicinal Chemistry is an essential journal for every medicinal and pharmaceutical chemist who wishes to be kept informed and up-to-date with the latest and most important developments.