[急性妊娠脂肪肝病例系列]。

IF 0.7 4区 医学 Q4 OBSTETRICS & GYNECOLOGY
Zeitschrift fur Geburtshilfe und Neonatologie Pub Date : 2023-12-01 Epub Date: 2023-07-25 DOI:10.1055/a-2096-6230
Martina Brügge, Ulrich Pecks, Antonella Iannaccone, Monika Palz-Fleige, Holger Stepan, Anne Tauscher
{"title":"[急性妊娠脂肪肝病例系列]。","authors":"Martina Brügge, Ulrich Pecks, Antonella Iannaccone, Monika Palz-Fleige, Holger Stepan, Anne Tauscher","doi":"10.1055/a-2096-6230","DOIUrl":null,"url":null,"abstract":"<p><p>With a prevalence of 0,01-0,03%, acute fatty liver in pregnancy (AFLP) is a rare and dangerous complication of pregnancy and is difficult to distinguish from other, sometimes more common, pregnancy diseases such as HELLP syndrome, aHUS and TTP because of its mostly non-specific symptoms. Due to its rarity, AFLP is often not obvious to the obstetrician as a possible differential diagnosis. Yet early diagnosis and the fastest possible delivery is the only causal therapy and is important for the mortality rate. In the present manuscript, the pathophysiology, diagnosis and therapy of acute fatty liver in pregnancy are highlighted for the clinical routine based on case descriptions from three university hospitals, and reference is made to possible findings that are helpful in establishing the diagnosis. The angiogenic preeclampsia marker sFlt-1 plays a role and provides new opportunities to consider pathophysiological approaches.</p>","PeriodicalId":23854,"journal":{"name":"Zeitschrift fur Geburtshilfe und Neonatologie","volume":null,"pages":null},"PeriodicalIF":0.7000,"publicationDate":"2023-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"[Acute Fatty Liver of Pregnancy - Case Series].\",\"authors\":\"Martina Brügge, Ulrich Pecks, Antonella Iannaccone, Monika Palz-Fleige, Holger Stepan, Anne Tauscher\",\"doi\":\"10.1055/a-2096-6230\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>With a prevalence of 0,01-0,03%, acute fatty liver in pregnancy (AFLP) is a rare and dangerous complication of pregnancy and is difficult to distinguish from other, sometimes more common, pregnancy diseases such as HELLP syndrome, aHUS and TTP because of its mostly non-specific symptoms. Due to its rarity, AFLP is often not obvious to the obstetrician as a possible differential diagnosis. Yet early diagnosis and the fastest possible delivery is the only causal therapy and is important for the mortality rate. In the present manuscript, the pathophysiology, diagnosis and therapy of acute fatty liver in pregnancy are highlighted for the clinical routine based on case descriptions from three university hospitals, and reference is made to possible findings that are helpful in establishing the diagnosis. The angiogenic preeclampsia marker sFlt-1 plays a role and provides new opportunities to consider pathophysiological approaches.</p>\",\"PeriodicalId\":23854,\"journal\":{\"name\":\"Zeitschrift fur Geburtshilfe und Neonatologie\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.7000,\"publicationDate\":\"2023-12-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Zeitschrift fur Geburtshilfe und Neonatologie\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1055/a-2096-6230\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2023/7/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"OBSTETRICS & GYNECOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Zeitschrift fur Geburtshilfe und Neonatologie","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1055/a-2096-6230","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2023/7/25 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}
引用次数: 0

摘要

妊娠期急性脂肪肝(AFLP)的患病率为0.01 - 0.03%,是一种罕见而危险的妊娠并发症,由于其症状多为非特异性,因此难以与其他更常见的妊娠疾病(如HELLP综合征、aHUS和TTP)区分。由于其罕见,AFLP往往不明显的产科医生作为一个可能的鉴别诊断。然而,早期诊断和尽可能快的分娩是唯一的因果治疗,对死亡率很重要。本文根据三所大学附属医院的病例描述,着重介绍了妊娠期急性脂肪肝的病理生理、诊断和治疗,并对可能有助于诊断的发现作了参考。血管生成性子痫前期标志物sFlt-1发挥了作用,并为考虑病理生理方法提供了新的机会。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
[Acute Fatty Liver of Pregnancy - Case Series].

With a prevalence of 0,01-0,03%, acute fatty liver in pregnancy (AFLP) is a rare and dangerous complication of pregnancy and is difficult to distinguish from other, sometimes more common, pregnancy diseases such as HELLP syndrome, aHUS and TTP because of its mostly non-specific symptoms. Due to its rarity, AFLP is often not obvious to the obstetrician as a possible differential diagnosis. Yet early diagnosis and the fastest possible delivery is the only causal therapy and is important for the mortality rate. In the present manuscript, the pathophysiology, diagnosis and therapy of acute fatty liver in pregnancy are highlighted for the clinical routine based on case descriptions from three university hospitals, and reference is made to possible findings that are helpful in establishing the diagnosis. The angiogenic preeclampsia marker sFlt-1 plays a role and provides new opportunities to consider pathophysiological approaches.

求助全文
通过发布文献求助,成功后即可免费获取论文全文。 去求助
来源期刊
Zeitschrift fur Geburtshilfe und Neonatologie
Zeitschrift fur Geburtshilfe und Neonatologie OBSTETRICS & GYNECOLOGY-PEDIATRICS
CiteScore
1.10
自引率
0.00%
发文量
166
审稿时长
>12 weeks
期刊介绍: Gynäkologen, Geburtshelfer, Hebammen, Neonatologen, Pädiater
×
引用
GB/T 7714-2015
复制
MLA
复制
APA
复制
导出至
BibTeX EndNote RefMan NoteFirst NoteExpress
×
提示
您的信息不完整,为了账户安全,请先补充。
现在去补充
×
提示
您因"违规操作"
具体请查看互助需知
我知道了
×
提示
确定
请完成安全验证×
copy
已复制链接
快去分享给好友吧!
我知道了
右上角分享
点击右上角分享
0
联系我们:info@booksci.cn Book学术提供免费学术资源搜索服务,方便国内外学者检索中英文文献。致力于提供最便捷和优质的服务体验。 Copyright © 2023 布克学术 All rights reserved.
京ICP备2023020795号-1
ghs 京公网安备 11010802042870号
Book学术文献互助
Book学术文献互助群
群 号:481959085
Book学术官方微信