摩洛哥仙人掌乙醇提取物镇痛潜力的研究。

Q2 Medicine
Imad Adadi, Rachida El Ayadi, Lhoussain Hajji, Mohamed Eddouks, Hamid El Ibaoui
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引用次数: 0

摘要

研究目的:分析莲子的镇痛活性。背景:莲子是分布于地中海盆地的一种菊科芳香灌木,具有多种生物活性,包括抗糖尿病和降压作用。目的:本工作的目的是研究在摩洛哥北部采集的Cistus ladanifer L.(C.ladanifer)的乙醇提取物的植物化学特征、急性毒性和镇痛能力,福尔马林致小鼠舔爪模型和醋酸致小鼠扭体实验。结果:采用高效液相色谱-质谱联用技术从乙醇提取物中鉴定出5种酚类化合物。关于急性毒性研究,结果显示,与对照组相比,剂量高达5000 mg/kg BW的小鼠没有死亡或临床症状。关于镇痛效果,400和800 mg/kg剂量的乙醇提取物,BW显示出统计学意义(p结论:这些发现提供了药理学依据,可能有助于开发一种天然的抗伤害药物,作为化学镇痛药物的替代品。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Study of the Analgesic Potential of the Ethanolic Extract of Moroccan Cistus ladanifer L.

Aims: The study aimed to analyze the analgesic activity of Cistus ladanifer L.

Background: Cistus ladanifer L. is a fragrant shrub of the Cistaceae family widespread in the Mediterranean basin, it has various biological activities, including antidiabetic and antihypertensive effects.

Objectives: The objective of this work was to study the phytochemical profile, the acute toxicity and the analgesic power of the ethanolic extract of the species Cistus ladanifer L. (C. ladanifer) collected in Northern Morocco.

Methods: The evaluation of antinociceptive activity in mice was performed using two validated models, the formalin-induced paw-licking model and the acetic acid-provoked writhing test.

Results: According to the results, five phenolic compounds were identified in the ethanolic extract by HPLC-MS/MS. As regards the acute toxicity study, the results showed no mortality or clinical symptoms in mice treated to compare the control group at doses up to 5,000 mg/kg BW. Regarding the analgesic effect, the ethanolic extract at the doses of 400 and 800 mg/kg, BW showed a statistically significant (p <0.05) and dose-dependent analgesic effect in two nociceptive tests. On the other hand, in the syrup of ethanolic extract at the dose of 800 mg/kg, BW expressed the most superior pain-inhibiting effect in both tests, producing an analgesic effect equivalent to that of the reference drug (indomethacin).

Conclusion: These findings provide pharmacological justification that might aid in the development of a natural anti-nociceptive medication as an alternative to chemical analgesic drugs.

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来源期刊
Cardiovascular and Hematological Disorders - Drug Targets
Cardiovascular and Hematological Disorders - Drug Targets Medicine-Cardiology and Cardiovascular Medicine
CiteScore
1.90
自引率
0.00%
发文量
36
期刊介绍: Cardiovascular & Hematological Disorders - Drug Targets aims to cover all the latest and outstanding developments on the medicinal chemistry, pharmacology, molecular biology, genomics and biochemistry of contemporary molecular targets involved in cardiovascular and hematological disorders e.g. disease specific proteins, receptors, enzymes, genes. Each issue of the journal contains a series of timely in-depth reviews written by leaders in the field covering a range of current topics on drug targets involved in cardiovascular and hematological disorders. As the discovery, identification, characterization and validation of novel human drug targets for cardiovascular and hematological drug discovery continues to grow.
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