Yajie Ding, Zongzhe Tang, Minxian Wang, Min Wang, Ru Zhang, Liuxin Zhang, Mengting Zhang, Qing Guan, Jie Wang
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The associations of SUA and FLI with NAFLD were analyzed using linear correlation, multiple linear regressions, binary logistic analyses, and area under receiver-operating characteristic curve (AUROC).</p><p><strong>Results: </strong>A total of 3,499 people were included in this study, of which 36.9% had NAFLD. The prevalence of NAFLD increased with the increase of SUA levels (all P <.05). Logistic regression analyses revealed that SUA was significantly associated with an increased risk of NAFLD (all P <.001). The NAFLD predictive value after combining SUA with FLI was superior to FLI, especially in females (AUROC<sub>SUA + FLI</sub> = 0.911 vs. AUROC<sub>FLI</sub> = 0.903, P <.05). The reclassification of NAFLD also significantly improved, based on net reclassification improvement (0.053, 95% confidence interval [CI]: 0.022-0.085, P <.001) and integrated discrimination improvement (0.096, 95% CI: 0.090-0.102, P <.001). A regression formula of this combined algorithm was proposed as: The novel formula = 0.032* waist circumference + 0.303* body mass index + 1.301* natural logarithm of triglyceride + 0.478* natural logarithm of glutamyl transpeptidase + 0.002* SUA- 18.823. At the cutoff value of 13.3, the sensitivity and specificity of this model were 89.2% and 78.4%, respectively.</p><p><strong>Conclusions: </strong>SUA level was positively associated with NAFLD prevalence. 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引用次数: 0
摘要
背景:血清尿酸(SUA)与非酒精性脂肪性肝病(NAFLD)之间的显著关联已被充分证实。在本报告中，我们验证了SUA可能改善被广泛研究的脂肪肝指数(FLI)以预测NAFLD的假设。方法:在中国南京的一个社区进行横断面研究。收集2018年7 - 9月的社会人口统计、体格检查和生化检测等人口数据。采用线性相关、多元线性回归、二元logistic分析和受试者工作特征曲线下面积(AUROC)分析SUA和FLI与NAFLD的相关性。结果:本研究共纳入3499人，其中36.9%的人患有NAFLD。随着SUA水平的升高，NAFLD患病率增加(所有P SUA + FLI = 0.911 vs. AUROCFLI = 0.903, P)。结论:SUA水平与NAFLD患病率呈正相关。与FLI相比，将SUA与FLI结合的新公式可能作为预测NAFLD的更好指标，特别是在女性中。
Combining serum uric acid and fatty liver index to improve prediction quality of nonalcoholic fatty liver disease.
Background: The significant association between serum uric acid (SUA) and nonalcoholic fatty liver disease (NAFLD) is well documented. In this report, we tested the hypothesis that SUA might improve the widely studied fatty liver index (FLI) to predict NAFLD.
Methods: A cross-sectional study was performed in a community of Nanjing, China. The population data on sociodemographics, physical examinations, and biochemical tests were collected from July to September 2018. The associations of SUA and FLI with NAFLD were analyzed using linear correlation, multiple linear regressions, binary logistic analyses, and area under receiver-operating characteristic curve (AUROC).
Results: A total of 3,499 people were included in this study, of which 36.9% had NAFLD. The prevalence of NAFLD increased with the increase of SUA levels (all P <.05). Logistic regression analyses revealed that SUA was significantly associated with an increased risk of NAFLD (all P <.001). The NAFLD predictive value after combining SUA with FLI was superior to FLI, especially in females (AUROCSUA + FLI = 0.911 vs. AUROCFLI = 0.903, P <.05). The reclassification of NAFLD also significantly improved, based on net reclassification improvement (0.053, 95% confidence interval [CI]: 0.022-0.085, P <.001) and integrated discrimination improvement (0.096, 95% CI: 0.090-0.102, P <.001). A regression formula of this combined algorithm was proposed as: The novel formula = 0.032* waist circumference + 0.303* body mass index + 1.301* natural logarithm of triglyceride + 0.478* natural logarithm of glutamyl transpeptidase + 0.002* SUA- 18.823. At the cutoff value of 13.3, the sensitivity and specificity of this model were 89.2% and 78.4%, respectively.
Conclusions: SUA level was positively associated with NAFLD prevalence. A new formula combining SUA with FLI may serve as a better indicator to predict NAFLD compared to FLI, especially in females.
期刊介绍：
Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance.
Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.
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