控制腔前卵泡向早期腔前卵泡过渡的机制以及建立有效的体外培养系统促进其生长的策略。

IF 1.5 4区生物学 Q4 CELL BIOLOGY

Zygote Pub Date : 2023-08-01 DOI:10.1017/S0967199423000254

D R Nascimento, E C Barbalho, L Gondim Barrozo, E I T de Assis, F C Costa, J R V Silva

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引用次数: 0

摘要

腔前卵泡向腔早期卵泡的转变是一个复杂的过程，受内分泌和旁分泌因素的调节，同时也受卵母细胞、颗粒细胞和卵泡细胞的精确相互作用的影响。了解卵泡形成的调控机制对改善体外培养系统具有重要意义，并为利用腔前卵泡卵母细胞辅助生殖技术开辟了新的视角。因此，本文旨在探讨控制颗粒细胞增殖和分化、窦腔形成、雌二醇产生、闭锁和窦腔早期卵泡过渡过程中卵泡液产生的内分泌和旁分泌机制。并讨论了促进腔前卵泡体外生长的策略。

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The mechanisms that control the preantral to early antral follicle transition and the strategies to have efficient culture systems to promote their growth in vitro.

Preantral to early antral follicles transition is a complex process regulated by endocrine and paracrine factors, as well as by a precise interaction among oocyte, granulosa cells and theca cells. Understanding the mechanisms that regulate this step of folliculogenesis is important to improve in vitro culture systems, and opens new perspectives to use oocytes from preantral follicles for assisted reproductive technologies. Therefore, this review aims to discuss the endocrine and paracrine mechanisms that control granulosa cell proliferation and differentiation, formation of the antral cavity, estradiol production, atresia, and follicular fluid production during the transition from preantral to early antral follicles. The strategies that promote in vitro growth of preantral follicles are also discussed.

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来源期刊

Zygote 生物-发育生物学

CiteScore

1.70

自引率

5.90%

发文量

117

审稿时长

6-12 weeks

期刊介绍： An international journal dedicated to the rapid publication of original research in early embryology, Zygote covers interdisciplinary studies on gametogenesis through fertilization to gastrulation in animals and humans. The scope has been expanded to include clinical papers, molecular and developmental genetics. The editors will favour work describing fundamental processes in the cellular and molecular mechanisms of animal development, and, in particular, the identification of unifying principles in biology. Nonetheless, new technologies, review articles, debates and letters will become a prominent feature.