J Asha, Nithya M Baiju, Susheela J Innah, Aboobacker Rafi, Bins M John
{"title":"基于血小板输注的登革热患者血小板指数比较：一项在三级护理中心进行的前瞻性观察研究。","authors":"J Asha, Nithya M Baiju, Susheela J Innah, Aboobacker Rafi, Bins M John","doi":"10.4103/ajts.AJTS_24_20","DOIUrl":null,"url":null,"abstract":"<p><strong>Context: </strong>Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.</p><p><strong>Aims: </strong>This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.</p><p><strong>Settings and design: </strong>Prospective observational study in a tertiary care center, Thrissur, Kerala.</p><p><strong>Subjects and methods: </strong>A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.</p><p><strong>Statistical analysis used: </strong>Independent <i>t</i>-test, Chi-square test, Karl Pearson correlation coefficient.</p><p><strong>Results: </strong>A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.</p><p><strong>Conclusions: </strong>PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.</p>","PeriodicalId":42296,"journal":{"name":"Asian Journal of Transfusion Science","volume":"17 1","pages":"21-27"},"PeriodicalIF":0.6000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/61/AJTS-17-21.PMC10180782.pdf","citationCount":"0","resultStr":"{\"title\":\"Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center.\",\"authors\":\"J Asha, Nithya M Baiju, Susheela J Innah, Aboobacker Rafi, Bins M John\",\"doi\":\"10.4103/ajts.AJTS_24_20\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Context: </strong>Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.</p><p><strong>Aims: </strong>This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.</p><p><strong>Settings and design: </strong>Prospective observational study in a tertiary care center, Thrissur, Kerala.</p><p><strong>Subjects and methods: </strong>A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.</p><p><strong>Statistical analysis used: </strong>Independent <i>t</i>-test, Chi-square test, Karl Pearson correlation coefficient.</p><p><strong>Results: </strong>A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.</p><p><strong>Conclusions: </strong>PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.</p>\",\"PeriodicalId\":42296,\"journal\":{\"name\":\"Asian Journal of Transfusion Science\",\"volume\":\"17 1\",\"pages\":\"21-27\"},\"PeriodicalIF\":0.6000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/6f/61/AJTS-17-21.PMC10180782.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Asian Journal of Transfusion Science\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.4103/ajts.AJTS_24_20\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2022/12/12 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"Q4\",\"JCRName\":\"HEMATOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Asian Journal of Transfusion Science","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.4103/ajts.AJTS_24_20","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2022/12/12 0:00:00","PubModel":"Epub","JCR":"Q4","JCRName":"HEMATOLOGY","Score":null,"Total":0}
Comparison of platelet indices in dengue fever patients based on platelet transfusion: A prospective observational study in a tertiary care center.
Context: Dengue fever is the most prevalent mosquito-borne viral disease in humans. Platelet indices (PIs) are given by the cell counters but are often not reported which is possibly due to under-recognition of the utility of these parameters.
Aims: This study aimed to compare PIs in patients with dengue fever to assess their role in the outcome such as hospital stay and platelet transfusion requirements.
Settings and design: Prospective observational study in a tertiary care center, Thrissur, Kerala.
Subjects and methods: A group of 250 dengue patients was studied over a period of 18 months. The platelet parameters (platelet count, mean platelet volume [MPV], platelet distribution width [PDW], platelet large cell ratio [PLCR], plateletcrit [PCT] and immature platelet fraction [IPF]) were measured with Sysmex XN-1000 and followed up every 24 h. The clinical features, duration of hospital stay and platelet transfusion requirements details were collected.
Results: A total of sample size was 250. The study showed normal PDW and MPV, low platelet count and PCT, and high PLCR and IPF in dengue patients. There were significant differences in PIs (lower platelet count and PCT, higher MPV, PDW, PLCR, and IPF) in comparison between dengue patients based on platelet transfusion.
Conclusions: PIs may act as a predictive tool in the diagnosis and predicting outcomes in dengue fever. Low platelet count and PCT, high PDW, MPV, PLCR, and IPF in transfused dengue patients were found to be statistically significant. Clinicians need to be sensitized about the utility and limitations of these indices and rationalize the need for red cell and platelet transfusions in dengue.
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