Juuso Stenbäck, Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Sirpa Hartikainen, Pekka Ylöstalo
{"title":"老年人高抗胆碱能负荷与低唾液和口干。","authors":"Juuso Stenbäck, Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Sirpa Hartikainen, Pekka Ylöstalo","doi":"10.1080/00016357.2023.2166105","DOIUrl":null,"url":null,"abstract":"<p><strong>Objective: </strong>The aim was to study the association between high anticholinergic burden and hyposalivation and xerostomia among older people.</p><p><strong>Background: </strong>Anticholinergic drugs have been shown to cause xerostomia and hyposalivation. Yet there are few studies on the association between anticholinergic burden and hyposalivation and xerostomia in the elderly.</p><p><strong>Material and methods: </strong>The study population consisted of community-dwelling older people (<i>n</i> = 321, mean age 81.6 years) from the Oral health GeMS study. Participants provided salivary samples and xerostomia was determined with a questionnaire. The baseline data were collected by interviews, oral clinical examinations and from patient records. Each participant's anticholinergic burden was determined by eight anticholinergic scales. Poisson regression models with robust error variance were used to estimate relative risks (RR) with a 95% confidence interval (CI).</p><p><strong>Results: </strong>RRs of high anticholinergic burden in anticholinergic scales for xerostomia (multiple symptoms) ranged from 1.02 to 1.68; for low unstimulated salivary flow (≤0.1 mL/min) from 1.47 to 1.67; and for low stimulated salivary flow (≤0.7 mL/min) from 0.99 to 2.07. A high anticholinergic burden according to seven out of eight scales was associated (<i>p</i> < .05) with hyposalivation or xerostomia.</p><p><strong>Conclusions: </strong>A high anticholinergic burden was associated more strongly with hyposalivation (both unstimulated and stimulated) than with xerostomia.</p>","PeriodicalId":7313,"journal":{"name":"Acta Odontologica Scandinavica","volume":null,"pages":null},"PeriodicalIF":1.4000,"publicationDate":"2023-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"High anticholinergic burden and hyposalivation and xerostomia in the elderly.\",\"authors\":\"Juuso Stenbäck, Antti Tiisanoja, Anna-Maija Syrjälä, Kaija Komulainen, Sirpa Hartikainen, Pekka Ylöstalo\",\"doi\":\"10.1080/00016357.2023.2166105\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Objective: </strong>The aim was to study the association between high anticholinergic burden and hyposalivation and xerostomia among older people.</p><p><strong>Background: </strong>Anticholinergic drugs have been shown to cause xerostomia and hyposalivation. Yet there are few studies on the association between anticholinergic burden and hyposalivation and xerostomia in the elderly.</p><p><strong>Material and methods: </strong>The study population consisted of community-dwelling older people (<i>n</i> = 321, mean age 81.6 years) from the Oral health GeMS study. Participants provided salivary samples and xerostomia was determined with a questionnaire. The baseline data were collected by interviews, oral clinical examinations and from patient records. Each participant's anticholinergic burden was determined by eight anticholinergic scales. Poisson regression models with robust error variance were used to estimate relative risks (RR) with a 95% confidence interval (CI).</p><p><strong>Results: </strong>RRs of high anticholinergic burden in anticholinergic scales for xerostomia (multiple symptoms) ranged from 1.02 to 1.68; for low unstimulated salivary flow (≤0.1 mL/min) from 1.47 to 1.67; and for low stimulated salivary flow (≤0.7 mL/min) from 0.99 to 2.07. A high anticholinergic burden according to seven out of eight scales was associated (<i>p</i> < .05) with hyposalivation or xerostomia.</p><p><strong>Conclusions: </strong>A high anticholinergic burden was associated more strongly with hyposalivation (both unstimulated and stimulated) than with xerostomia.</p>\",\"PeriodicalId\":7313,\"journal\":{\"name\":\"Acta Odontologica Scandinavica\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":1.4000,\"publicationDate\":\"2023-08-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Acta Odontologica Scandinavica\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.1080/00016357.2023.2166105\",\"RegionNum\":4,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"DENTISTRY, ORAL SURGERY & MEDICINE\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Acta Odontologica Scandinavica","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1080/00016357.2023.2166105","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"DENTISTRY, ORAL SURGERY & MEDICINE","Score":null,"Total":0}
High anticholinergic burden and hyposalivation and xerostomia in the elderly.
Objective: The aim was to study the association between high anticholinergic burden and hyposalivation and xerostomia among older people.
Background: Anticholinergic drugs have been shown to cause xerostomia and hyposalivation. Yet there are few studies on the association between anticholinergic burden and hyposalivation and xerostomia in the elderly.
Material and methods: The study population consisted of community-dwelling older people (n = 321, mean age 81.6 years) from the Oral health GeMS study. Participants provided salivary samples and xerostomia was determined with a questionnaire. The baseline data were collected by interviews, oral clinical examinations and from patient records. Each participant's anticholinergic burden was determined by eight anticholinergic scales. Poisson regression models with robust error variance were used to estimate relative risks (RR) with a 95% confidence interval (CI).
Results: RRs of high anticholinergic burden in anticholinergic scales for xerostomia (multiple symptoms) ranged from 1.02 to 1.68; for low unstimulated salivary flow (≤0.1 mL/min) from 1.47 to 1.67; and for low stimulated salivary flow (≤0.7 mL/min) from 0.99 to 2.07. A high anticholinergic burden according to seven out of eight scales was associated (p < .05) with hyposalivation or xerostomia.
Conclusions: A high anticholinergic burden was associated more strongly with hyposalivation (both unstimulated and stimulated) than with xerostomia.