药物发现与毒理学的最新进展。

IF 1.2 4区 医学 Q4 PHARMACOLOGY & PHARMACY
International Journal of Toxicology Pub Date : 2023-12-01 Epub Date: 2023-07-15 DOI:10.1177/10915818231189659
Bowen Tang, Vijay More
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引用次数: 0

摘要

科学发现和见解的重大进展源于新技术和模型的开发和使用,可以为传统毒理学带来显著进步。尽管动物试验仍然被认为是传统毒性试验的“金标准”,但由于新兴的技术和3R(取代、减少和完善)对动物福利的建议,有必要从动物试验转向药物安全性试验的替代方法。这篇综述介绍了药物发现毒理学的一些最新研究方法,包括体外细胞和芯片上的器官、成像系统、模式生物(秀丽隐杆线虫、灰蝶和黑腹果蝇)以及现代毒理学测试中的毒代基因组学。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Recent Advances in Drug Discovery Toxicology.

Major advances in scientific discovery and insights that stem from the development and use of new techniques and models can bring remarkable progress to conventional toxicology. Although animal testing is still considered as the "gold standard" in traditional toxicity testing, there is a necessity for shift from animal testing to alternative methods regarding the drug safety testing owing to the emerging state-of-art techniques and the proposal of 3Rs (replace, reduce, and refine) towards animal welfare. This review describes some recent research methods in drug discovery toxicology, including in vitro cell and organ-on-a-chip, imaging systems, model organisms (C. elegans, Danio rerio, and Drosophila melanogaster), and toxicogenomics in modern toxicology testing.

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来源期刊
CiteScore
3.40
自引率
4.50%
发文量
53
审稿时长
4.5 months
期刊介绍: The International Journal of Toxicology publishes timely, peer-reviewed papers on current topics important to toxicologists. Six bi-monthly issues cover a wide range of topics, including contemporary issues in toxicology, safety assessments, novel approaches to toxicological testing, mechanisms of toxicity, biomarkers, and risk assessment. The Journal also publishes invited reviews on contemporary topics, and features articles based on symposia. In addition, supplemental issues are routinely published on various special topics, including three supplements devoted to contributions from the Cosmetic Review Expert Panel.
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