[采用 HPLC-MS/MS 方法对蓖麻毒素中毒进行法医化学和化学毒理学检验]。

Q4 Medicine

Sudebno-Meditsinskaya Ekspertisa Pub Date : 2023-01-01 DOI:10.17116/sudmed20236603134

R A Kalekin, S S Barseghyan, A A Volkova, A M Orlova, V D Akimova

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引用次数: 1

摘要

研究目的提出在法医和化学毒理学检查过程中测定生物液体中蓖麻毒素含量的方法。这项研究描述了生物液体样品处理的最佳条件，以便提取蓖麻籽中的成分（蓖麻毒素和蓖麻油酸）。根据推荐的分析条件，可在 15 分钟内通过高分辨率质谱法结合色谱-质谱仪上的高值液相色谱法进行研究，以检测蓖麻毒素和蓖麻油酸。色谱（保留时间）和质谱参数（质谱）已确定，可准确、高质量地测定蓖麻碱和蓖麻油酸。

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[Forensic chemical and chemicotoxicological examination of ricin poisoning by the HPLC-MS/MS method].

The aim of the study: Is to suggest the method of ricin determination in biological liquids during forensic medical and chemicotoxicological examination. This research describes the optimal conditions of sample processing of biological liquids, allowing to extract the components (ricinine and ricinoleic acid) of castor seeds. The recommended analysis conditions allow to perform research for 15 minutes by high resolution mass spectrometry method combined with high-value liquid chromatography on a chromato-mass spectrometer to detect ricinine and ricinoleic acid. The chromatographic (retention time) and mass-spectrometric parameters (mass spectra) were established for the exact high-quality determination of ricinine and ricinoleic acid.

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来源期刊

Sudebno-Meditsinskaya Ekspertisa Medicine-Pathology and Forensic Medicine

CiteScore

0.60

自引率

0.00%

发文量

期刊介绍： The journal is concerned with the theory and practice of forensic medicine - the problems of thanatology, traumatology, toxicology, serology, forensic obstetrics, forensic dentistry, forensic psychiatry, forensic chemistry, physicotechnical methods of investigation, history of forensic medicine and some problems of criminology and legal laws related to forensic medicine. It publishes original studies by Russian authors, casuistry surveys, abstracts and reviews of Russian and foreign literature, scientific information, reports on scientific conferences.