利用脂质-DNA 共轭物挖掘细胞膜的生物物理特征。

IF 7.2 2区生物学 Q1 BIOPHYSICS

Quarterly Reviews of Biophysics Pub Date : 2022-05-16 DOI:10.1017/S003358352200004X

Ahsan Ausaf Ali, Yousef Bagheri, Mingxu You

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引用次数: 0

摘要

脂质-DNA 共轭物已成为改变细胞膜的非常有用的工具。这些共轭物一般由用于膜修饰的脂质锚和用于膜分析或调节的功能性 DNA 纳米结构组成。这些脂质-DNA 共轭物有几种独特的性质，特别是可编程性、快速高效的膜插入和精确的序列特异性组装。这些独特的特性使得它们在活细胞膜上的生物物理应用变得十分广泛。在这篇综述中，我们将主要关注最近，尤其是过去三年中，在调节这些脂质-DNA 共轭物的生物物理特性及其在研究细胞膜生物物理方面的关键应用方面取得的巨大进展。此外，我们还对这一跨学科领域当前面临的挑战和未来发展方向提出了一些见解。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Digging into the biophysical features of cell membranes with lipid-DNA conjugates.

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Digging into the biophysical features of cell membranes with lipid-DNA conjugates.

Lipid-DNA conjugates have emerged as highly useful tools to modify the cell membranes. These conjugates generally consist of a lipid anchor for membrane modification and a functional DNA nanostructure for membrane analysis or regulation. There are several unique properties of these lipid-DNA conjugates, especially including their programmability, fast and efficient membrane insertion, and precise sequence-specific assembly. These unique properties have enabled a broad range of biophysical applications on live cell membranes. In this review, we will mainly focus on recent tremendous progress, especially during the past three years, in regulating the biophysical features of these lipid-DNA conjugates and their key applications in studying cell membrane biophysics. Some insights into the current challenges and future directions of this interdisciplinary field have also been provided.

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来源期刊

Quarterly Reviews of Biophysics 生物-生物物理

CiteScore

12.90

自引率

1.60%

发文量

期刊介绍： Quarterly Reviews of Biophysics covers the field of experimental and computational biophysics. Experimental biophysics span across different physics-based measurements such as optical microscopy, super-resolution imaging, electron microscopy, X-ray and neutron diffraction, spectroscopy, calorimetry, thermodynamics and their integrated uses. Computational biophysics includes theory, simulations, bioinformatics and system analysis. These biophysical methodologies are used to discover the structure, function and physiology of biological systems in varying complexities from cells, organelles, membranes, protein-nucleic acid complexes, molecular machines to molecules. The majority of reviews published are invited from authors who have made significant contributions to the field, who give critical, readable and sometimes controversial accounts of recent progress and problems in their specialty. The journal has long-standing, worldwide reputation, demonstrated by its high ranking in the ISI Science Citation Index, as a forum for general and specialized communication between biophysicists working in different areas. Thematic issues are occasionally published.