快速发展的近红外光免疫疗法为现代癌症治疗提供了多方面的方法。

View (Beijing, China) Pub Date : 2022-05-01 Epub Date: 2021-08-27 DOI:10.1002/VIW.20200110
Hailey Monaco, Shinya Yokomizo, Hak Soo Choi, Satoshi Kashiwagi
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引用次数: 0

摘要

在癌症免疫疗法中,近红外光免疫疗法(NIR-PIT)已进入重要的临床前和临床阶段,并在过去五年中迅速发展。近红外光免疫疗法利用深穿透的近红外光诱导抗体-光敏剂共轭物(APC)发生物理化学变化,导致癌细胞坏死和免疫原性细胞死亡(ICD)。另外,其他类型的光医疗使用光敏剂将吸收的光能转化为活性氧,用于光动力疗法(PDT),或转化为热能,用于光热疗法(PTT)。ICD 是近红外-PIT 的一种独特的相关结果,因为它能诱导持久的抗肿瘤宿主免疫,从而克服癌症的免疫抑制网络。由于其高度特异性和持久的抗肿瘤效果,近红外-PIT 现在被认为是一种很有前景的癌症疗法,优化的近红外-PIT 正随时将其适用范围扩大到许多不同类型的癌症。除了传统的 NIR-PIT 方法外,目前还在探索其治疗领域的新途径,例如靶向其他免疫抑制因素、通过导管输送 NIR 光、实时成像检测肿瘤,以及使用肿瘤靶向小分子来提高疗效和安全性。此外,近红外光对高渗透性的影响也为与其他方式的广泛联合疗法打开了一扇大门。本综述总结了近红外诱导光医学临床和临床前研究的最新发现及其在癌症研究领域的未来意义。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.

Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.

Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.

Quickly evolving near-infrared photoimmunotherapy provides multifaceted approach to modern cancer treatment.

Among modalities of cancer immunotherapy, near-infrared photoimmunotherapy (NIR-PIT) has reached significant preclinical and clinical stages and quickly evolved over the last 5 years. NIR-PIT uses deep-penetrable NIR light to induce physicochemical changes in the antibody-photosensitizer conjugate (APC), leading to resultant necrosis and immunogenic cell death (ICD) of the cancer cells. Alternatively, other types of photomedicine use photosensitizers to convert absorbed light energy either into reactive oxygen species for photodynamic therapy (PDT) or into heat for photothermal therapy (PTT). ICD is a unique and relevant outcome of NIR-PIT because it induces long-lasting antitumor host immunity, which overcomes the immunosuppressive network of cancer. Due to its high specificity and durable antitumor effects, NIR-PIT is now considered a promising cancer therapy, and optimized NIR-PIT is readily expanding its applicability to many different types of cancer. Along with the traditional method of NIR-PIT, new avenues in its realm of treatment are currently being explored, such as the targeting of other immunosuppressive elements, delivery of NIR light through a catheter, real-time imaging for tumor detection, and the use of tumor-seeking small molecules for improved efficacy and safety. In addition, its effect on hyperpermeability has opened a door for a wide array of combination therapies with other modalities. This review summarizes the recent findings in clinical and preclinical studies of NIR-induced photomedicine and its future significance in the field of cancer research.

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