多西环素在二甲胺四环素诱发狼疮患者中的应用。

Katherine Quinn Newman, Charles Guy Castles
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引用次数: 0

摘要

二甲胺四环素是一种四环素抗生素,通常用于治疗酒渣鼻和寻常性痤疮。米诺环素使用的一个罕见的不良反应是药物性狼疮的发展。幸运的是,大多数患者在停药后从二甲胺四环素诱导的狼疮(MIL)中恢复。然而,许多患者,从MIL恢复后,可能希望进一步治疗他们的痤疮,并可能考虑多西环素,米诺环素的近亲。虽然没有多西环素诱发狼疮的病例报道,但在医学文献中很少有关于多西环素对MIL康复患者是否有特殊风险的指导。我们报告了一名MIL康复患者的长期随访(诊断符合临床和实验室标准),并使用各种形式的多西环素治疗8年,没有任何不良反应,这表明,至少在某些情况下,多西环素在MIL后可以安全使用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Use of Doxycycline in a Patient following Minocycline-Induced Lupus.

Minocycline, a tetracycline antibiotic, is commonly used to treat rosacea and acne vulgaris. A rare adverse reaction of minocycline use is the development of drug-induced lupus. Fortunately, most patients recover from minocycline-induced lupus (MIL) after the drug is discontinued. However, many patients, after recovering from MIL, may desire further treatment for their acne and may consider doxycycline, a close relative of minocycline. Though no cases of doxycycline-induced lupus have been reported, there is little guidance in the medical literature as to whether doxycycline poses a particular risk to patients who have recovered from MIL. We report the long-term follow-up of a patient who recovered from MIL (the diagnosis satisfying clinical and laboratory criteria) and was treated for 8 years with various forms of doxycycline without any untoward effects, suggesting that, at least in some cases, doxycycline can be used safely following MIL.

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