转移性肺多形性癌累及空肠:1例报告及文献复习。

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2023-01-01

Fei Han, Mohammed Osmani, Michael Jaronczyk, Yong Kang

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引用次数: 0

摘要

我们提出一个病例报告的肺多形性癌转移到空肠在一个80岁的妇女。患者因持续数月的症状性贫血和黑黑而入院。2021年，通过细针穿刺诊断为非小细胞癌。2022年，计算机断层扫描(CT)显示小肠内有一个巨大的肿块。切除肿瘤后发现肿瘤细胞形态多形性，呈巨细胞和梭形细胞形态。这些肿瘤细胞甲状腺转录因子1 (TTF1)阳性。继发性肿瘤的下一代测序显示97%的基因组与肺肿瘤相似，程序性细胞死亡配体1 (PD-L1)高表达。患者可能受益于免疫检查点疗法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

本刊更多论文

Metastatic pulmonary pleomorphic carcinoma involving the jejunum: a case report and review of the literature.

We present a case report of a pulmonary pleomorphic carcinoma that metastasized to the jejunum in an 80-year-old woman. The patient was admitted to the hospital with symptomatic anemia and melena that had been ongoing for several months. In 2021, non-small cell carcinoma was diagnosed by fine-needle aspiration. In 2022, a computed tomography (CT) scan revealed an enormous mass in the small bowel. The tumor was resected and showed pleomorphic neoplastic cells with giant and spindle cell morphology. These neoplastic cells were positive for thyroid transcription factor 1 (TTF1). Next-generation sequencing of the secondary tumor revealed 97% genomic similarities to the lung tumor and high expression of programmed cell death ligand 1 (PD-L1). The patient may benefit from immune checkpoint therapy.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.