Hunter Richards, Samir Alsalek, Azim Laiwalla, Mark Attiah, Maya Harary, Wi Jin Kim, Daniel Hirt, Shayan U Rahman
{"title":"子宫平滑肌肉瘤的脑和肺转移:一个例证性病例。","authors":"Hunter Richards, Samir Alsalek, Azim Laiwalla, Mark Attiah, Maya Harary, Wi Jin Kim, Daniel Hirt, Shayan U Rahman","doi":"10.3171/CASE22557","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>Uterine leiomyosarcoma is a rare, extremely aggressive tumor with a high rate of metastasis. Five-year survival for individuals with metastatic disease is only 10%-15%. Metastases to the brain are exceptionally rare and are associated with poor survival.</p><p><strong>Observations: </strong>The authors report a case of uterine leiomyosarcoma that metastasized to the brain in a 51-year-old woman. A single lesion on magnetic resonance imaging was discovered in the right posterior temporo-occipital region 44 months after resection of the primary uterine tumor. The patient underwent a right occipital craniotomy with gross-total resection of the tumor and is receiving adjuvant stereotactic radiosurgery and chemotherapy with gemcitabine and docetaxel. At 8 months postresection, the patient remains alive and asymptomatic with no sign of recurrence. A literature review of prior reported cases was conducted to analyze patterns of approach to patient treatment and survival.</p><p><strong>Lessons: </strong>The authors found an apparent survival benefit in patients receiving adjuvant radiation therapy.</p>","PeriodicalId":16554,"journal":{"name":"Journal of Neurosurgery: Case Lessons","volume":"5 19","pages":""},"PeriodicalIF":0.0000,"publicationDate":"2023-05-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/95/CASE22557.PMC10550687.pdf","citationCount":"0","resultStr":"{\"title\":\"Brain and lung metastasis of uterine leiomyosarcoma: illustrative case.\",\"authors\":\"Hunter Richards, Samir Alsalek, Azim Laiwalla, Mark Attiah, Maya Harary, Wi Jin Kim, Daniel Hirt, Shayan U Rahman\",\"doi\":\"10.3171/CASE22557\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong>Uterine leiomyosarcoma is a rare, extremely aggressive tumor with a high rate of metastasis. Five-year survival for individuals with metastatic disease is only 10%-15%. Metastases to the brain are exceptionally rare and are associated with poor survival.</p><p><strong>Observations: </strong>The authors report a case of uterine leiomyosarcoma that metastasized to the brain in a 51-year-old woman. A single lesion on magnetic resonance imaging was discovered in the right posterior temporo-occipital region 44 months after resection of the primary uterine tumor. The patient underwent a right occipital craniotomy with gross-total resection of the tumor and is receiving adjuvant stereotactic radiosurgery and chemotherapy with gemcitabine and docetaxel. At 8 months postresection, the patient remains alive and asymptomatic with no sign of recurrence. A literature review of prior reported cases was conducted to analyze patterns of approach to patient treatment and survival.</p><p><strong>Lessons: </strong>The authors found an apparent survival benefit in patients receiving adjuvant radiation therapy.</p>\",\"PeriodicalId\":16554,\"journal\":{\"name\":\"Journal of Neurosurgery: Case Lessons\",\"volume\":\"5 19\",\"pages\":\"\"},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-05-08\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://ftp.ncbi.nlm.nih.gov/pub/pmc/oa_pdf/0c/95/CASE22557.PMC10550687.pdf\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Journal of Neurosurgery: Case Lessons\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.3171/CASE22557\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Journal of Neurosurgery: Case Lessons","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.3171/CASE22557","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Brain and lung metastasis of uterine leiomyosarcoma: illustrative case.
Background: Uterine leiomyosarcoma is a rare, extremely aggressive tumor with a high rate of metastasis. Five-year survival for individuals with metastatic disease is only 10%-15%. Metastases to the brain are exceptionally rare and are associated with poor survival.
Observations: The authors report a case of uterine leiomyosarcoma that metastasized to the brain in a 51-year-old woman. A single lesion on magnetic resonance imaging was discovered in the right posterior temporo-occipital region 44 months after resection of the primary uterine tumor. The patient underwent a right occipital craniotomy with gross-total resection of the tumor and is receiving adjuvant stereotactic radiosurgery and chemotherapy with gemcitabine and docetaxel. At 8 months postresection, the patient remains alive and asymptomatic with no sign of recurrence. A literature review of prior reported cases was conducted to analyze patterns of approach to patient treatment and survival.
Lessons: The authors found an apparent survival benefit in patients receiving adjuvant radiation therapy.