父母心血管健康与后代残疾调整寿命年的关系:来自弗雷明汉心脏研究的结果

IF 6.9 2区 医学
James M Muchira, Philimon N Gona, Mulubrhan F Mogos, Eileen M Stuart-Shor, Suzanne G Leveille, Mariann R Piano, Laura L Hayman
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引用次数: 0

摘要

背景:残障调整生命年(DALYs)用于评估人群中疾病的相对负担,以帮助确定预防或治疗重点。父母心血管健康(CVH)对成年后代心血管疾病(CVD)损失的健康寿命年的影响尚不清楚。我们比较了父母-后代CVD DALYs在整个生命过程中的趋势,并检查了父母CVH与后代CVD DALYs的关系。方法:使用弗雷明汉心脏研究的数据,4814名子女-母亲-父亲三人组在选定的基线检查中进行年龄匹配。CVH评分是根据CVH指标达到推荐水平的数量来计算的:差(0-2),中级(3-4)和理想(5-7)。CVD DALYs被定义为生命损失年数和患有CVD的年数之和。年龄-性别标准化预期寿命和残疾权重分别来自精算生命表和全球疾病负担研究。采用多变量调整线性回归研究亲代CVH与子代CVD DALYs的关系。结果:在47年的随访中,父母失去的CVD DALYs几乎是他们后代的两倍(23234对12217)。然而,年龄调整后的CVD DALYs在年轻时较高,并且在父母和后代的生命历程中相似。亲代CVH增加一个单位与后代节省5个健康生命月相关。CVH理想与不良母亲的后代可节省3年健康寿命(β=-3.0 DALYs [95% CI, -5.6至-0.3])。父亲CVH类型与后代CVD DALYs之间没有统计学意义的关联。结论:母亲和父亲较高的CVH与后代健康寿命年数增加有关;然而,母亲和子女之间的联系是最强的。在整个生命过程中促进心血管疾病的投资有可能减轻当前和未来一代成年人的心血管疾病负担。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Association of Parental Cardiovascular Health With Disability-Adjusted Life Years in the Offspring: Results From the Framingham Heart Study.

Background: Disability-adjusted life years (DALYs) are used to evaluate the relative burden of diseases in populations to help set prevention or treatment priorities. The impact of parental cardiovascular health (CVH) on healthy life years lost from cardiovascular disease (CVD) in adult offspring is unknown. We compared parent-offspring CVD DALYs trends over the life course and examined the association of parental CVH with offspring CVD DALYs.

Methods: Using data from the Framingham Heart Study, 4814 offspring-mother-father trios were matched for age at selected baseline exams. CVH score was computed from the number of CVH metrics attained at recommended levels: poor (0-2), intermediate (3-4), and ideal (5-7). CVD DALYs were defined as the sum of years of life lost and years lived with CVD. Age-sex-standardized life expectancy and disability weights were derived from the actuarial life tables and Global Burden of Disease study, respectively. Multivariable-adjusted linear regression was used to investigate the association of parental CVH with offspring CVD DALYs.

Results: Over an equal 47-year follow-up, parents lost nearly twice the number of CVD DALYs compared to their offspring (23 234 versus 12 217). However, age-adjusted CVD DALYs were higher at younger ages and similar along the life course for parents and offspring. One-unit increase in parental CVH was associated with 5 healthy life months saved in offspring. Offspring of mothers with ideal versus poor CVH had 3 healthy life years saved (β=-3.0 DALYs [95% CI, -5.6 to -0.3]). No statistically significant association was found between paternal CVH categories and offspring CVD DALYs.

Conclusions: Higher maternal and paternal CVH were associated with increased healthy life years in offspring; however, the association was strongest between mothers and offspring. Investment in CVH promotion along the life course has the potential to reduce the burden of CVD in the current and future generation of adults.

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来源期刊
Circulation. Cardiovascular Quality and Outcomes
Circulation. Cardiovascular Quality and Outcomes Medicine-Cardiology and Cardiovascular Medicine
CiteScore
9.80
自引率
2.90%
发文量
357
期刊介绍: Circulation: Cardiovascular Quality and Outcomes, an American Heart Association journal, publishes articles related to improving cardiovascular health and health care. Content includes original research, reviews, and case studies relevant to clinical decision-making and healthcare policy. The online-only journal is dedicated to furthering the mission of promoting safe, effective, efficient, equitable, timely, and patient-centered care. Through its articles and contributions, the journal equips you with the knowledge you need to improve clinical care and population health, and allows you to engage in scholarly activities of consequence to the health of the public. Circulation: Cardiovascular Quality and Outcomes considers the following types of articles: Original Research Articles, Data Reports, Methods Papers, Cardiovascular Perspectives, Care Innovations, Novel Statistical Methods, Policy Briefs, Data Visualizations, and Caregiver or Patient Viewpoints.
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