小胶质细胞生物学中的脂质——从物质到介质。

IF 5 3区医学 Q2 IMMUNOLOGY

Inflammation and Regeneration Pub Date : 2023-07-17 DOI:10.1186/s41232-023-00289-z

Shota Yamamoto, Takahiro Masuda

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引用次数: 0

摘要

小胶质细胞是中枢神经系统(CNS)中的巨噬细胞，在大脑发育和中枢神经系统疾病的发病过程中发挥着多种作用。近年来，小胶质细胞能量代谢的重编程被认为是小胶质细胞功能多样化的重要机制。脂质是高度多样化的物质，是每个细胞中细胞膜的重要组成部分。越来越多的证据表明，脂质及其代谢与小胶质细胞生物学密切相关。本文就小胶质细胞脂质代谢在健康和疾病中的作用作一综述。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

Lipid in microglial biology - from material to mediator.

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Lipid in microglial biology - from material to mediator.

Microglia are resident macrophages in the central nervous system (CNS) that play various roles during brain development and in the pathogenesis of CNS diseases. Recently, reprogramming of cellular energetic metabolism in microglia has drawn attention as a crucial mechanism for diversification of microglial functionality. Lipids are highly diverse materials and crucial components of cell membranes in every cell. Accumulating evidence has shown that lipid and its metabolism are tightly involved in microglial biology. In this review, we summarize the current knowledge about microglial lipid metabolism in health and disease.

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来源期刊

Inflammation and Regeneration Multiple-

CiteScore

11.10

自引率

1.20%

发文量

审稿时长

11 weeks

期刊介绍： Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.