双侧经颅直流电刺激促进脑室下区源性神经母细胞向缺血性脑迁移

IF 2.5 Q3 BIOCHEMISTRY & MOLECULAR BIOLOGY
Ruixue Lei, Shu Wang, Anchun Liu, Jing Cheng, Zhifeng Zhang, Jinyang Ren, Xujin Yao, Xiangyi Kong, Wenlong Ma, Fengyuan Che, Juan Chen, Qi Wan
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引用次数: 1

摘要

缺血性损伤刺激脑卒中后脑室下区(SVZ)神经干细胞(NSCs)的增殖。然而,只有一小部分来自SVZ的nsc来源的神经母细胞向卒中后脑区迁移。我们以前报道过,在体外,直流电刺激引导NSC向阴极迁移。为此,我们建立了一种新的经颅直流电刺激(tDCS)方法,将阴极电极置于缺血半脑,阳极电极置于对侧半脑。我们发现这种双侧tDCS (BtDCS)的应用促进了nsc来源的神经母细胞从SVZ向阴极方向迁移到脑卒中后纹状体。逆转电极位置可阻断BtDCS对SVZ神经母细胞迁移的影响。BtDCS可防止脑卒中动物神经元死亡,促进功能恢复。因此,nsc来源的神经母细胞从SVZ向脑卒中后脑区迁移有助于BtDCS对抗缺血诱导的神经元死亡,支持无创BtDCS作为内源性神经发生为基础的卒中治疗的潜在发展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Bilateral transcranial direct-current stimulation promotes migration of subventricular zone-derived neuroblasts toward ischemic brain

Bilateral transcranial direct-current stimulation promotes migration of subventricular zone-derived neuroblasts toward ischemic brain

Ischemic insult stimulates proliferation of neural stem cells (NSCs) in the subventricular zone (SVZ) after stroke. However, only a fraction of NSC-derived neuroblasts from SVZ migrate toward poststroke brain region. We have previously reported that direct-current stimulation guides NSC migration toward the cathode in vitro. Accordingly, we set up a new method of transcranial direct-current stimulation (tDCS), in which the cathodal electrode is placed on the ischemic hemisphere and anodal electrode on the contralateral hemisphere of rats subjected to ischemia–reperfusion injury. We show that the application of this bilateral tDCS (BtDCS) promotes the migration of NSC-derived neuroblasts from SVZ toward the cathode direction into poststroke striatum. Reversing the position of the electrodes blocks the effect of BtDCS on the migration of neuroblasts from SVZ. BtDCS protects against neuronal death and improves the functional recovery of stroke animals. Thus, the migration of NSC-derived neuroblasts from SVZ toward poststroke brain region contributes to the effect of BtDCS against ischemia-induced neuronal death, supporting a potential development of noninvasive BtDCS as an endogenous neurogenesis-based stroke therapy.

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来源期刊
FASEB bioAdvances
FASEB bioAdvances Multiple-
CiteScore
5.40
自引率
3.70%
发文量
56
审稿时长
10 weeks
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