作为化学渗透剂的 1,8-蒎烯的命运：综述。

IF 2.8 4区医学 Q2 PHARMACOLOGY & PHARMACY

Current drug delivery Pub Date : 2024-01-01 DOI:10.2174/1567201820666230509101602

Ligema Dao, Yu Dong, Lin Song, Chula Sa

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引用次数: 0

摘要

角质层仍然是透皮给药的最大障碍。化学渗透剂作为第一代透皮给药系统，具有很大的潜力。为了全面研究天然单萜类化合物 1,8-蒎烯的渗透机制，本综述总结了渗透促进剂对亲脂性和亲水性药物的影响，以及这种物质对皮肤和其他组织的毒性。对于亲脂性较低的药物，1,8-松油醇似乎具有更强的渗透促进作用。一种有效而安全的方法是将增强剂和剂型结合起来。1,8-ineole 因其渗透性和低毒性，有望在透皮给药系统中得到进一步开发，甚至成为脑部转运的候选药物。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Fate of 1,8-cineole as a Chemical Penetrant: A Review.

The stratum corneum continues to pose the biggest obstacle to transdermal drug delivery. Chemical penetrant, the first generation of transdermal drug delivery system, offers a lot of potential. In order to fully examine the permeation mechanism of 1,8-cineole, a natural monoterpene, this review summarizes the effects of permeation-enhancing medications on drugs that are lipophilic and hydrophilic as well as the toxicity of this substance on the skin and other tissues. For lower lipophilic drugs, 1,8-cineole appears to have a stronger osmotic-enhancing impact. An efficient and secure tactic would be to combine enhancers and dose forms. 1,8-cineole is anticipated to be further developed in the transdermal drug delivery system and even become a candidate drug for brain transport due to its permeability and low toxicity.

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来源期刊

Current drug delivery PHARMACOLOGY & PHARMACY-

CiteScore

5.10

自引率

4.20%

发文量

170

期刊介绍： Current Drug Delivery aims to publish peer-reviewed articles, research articles, short and in-depth reviews, and drug clinical trials studies in the rapidly developing field of drug delivery. Modern drug research aims to build delivery properties of a drug at the design phase, however in many cases this idea cannot be met and the development of delivery systems becomes as important as the development of the drugs themselves. The journal aims to cover the latest outstanding developments in drug and vaccine delivery employing physical, physico-chemical and chemical methods. The drugs include a wide range of bioactive compounds from simple pharmaceuticals to peptides, proteins, nucleotides, nucleosides and sugars. The journal will also report progress in the fields of transport routes and mechanisms including efflux proteins and multi-drug resistance. The journal is essential for all pharmaceutical scientists involved in drug design, development and delivery.