皮质类固醇在墨西哥总医院COVID-19住院患者中的作用

IF 0.5 4区医学 Q4 SURGERY

Cirugia Y Cirujanos Pub Date : 2023-01-01 DOI:10.24875/CIRU.22000233

Leonel Iturbide-Mauricio, Jessica Palacios-Vaca, Jesús R Calleja-López, Monserrat Pérez-Navarro, José A García-García, Ana M Espinosa-García

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引用次数: 0

摘要

目的:比较接受皮质类固醇为主治疗与接受标准治疗的SARS-CoV-2住院患者的演变情况。方法:回顾性、观察性和分析性研究。从不同的重症监护病房收集临床记录，并从住院的18岁以上确诊的COVID-19患者中获取数据。人群被分为两组:接受皮质类固醇治疗的患者和接受标准治疗的患者。结果:共收治患者1603例，其中死亡出院984例(62.9%)。主要结果为优势比鉴别(OR: 4.68;95%置信区间[95% CI]: 3.75-5.83;p = 0.001)与使用全身性类固醇以及使用有创机械通气的死亡风险(OR: 2.26;95% ci: 1.80-2.82;P < 0.001)。男性发病最多，共1051例(65.6%)。平均年龄56岁(±14岁)。结论:与接受标准治疗的COVID-19住院患者相比，皮质类固醇的使用与预后不良相关。

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The role of corticosteroids in patients hospitalized for COVID-19 at Mexico general Hospital.

Objective: To compare the evolution of hospitalized patients infected with SARS-CoV-2 who received corticosteroid-based treatment versus patients who received standard therapy.

Method: Retrospective, observational, and analytical study. Clinical records were collected from the different intensive care units, and data were obtained from confirmed COVID-19 patients over 18 years of age who were hospitalized. The population was divided into two groups: patients who received corticosteroid treatment, and those who received standard therapy.

Results: A total of 1603 patients were admitted to hospital, and of these 984 (62.9%) were discharged due to death. The main result was the identification by odds ratio (OR: 4.68; 95% confidence interval [95% CI]: 3.75-5.83; p = 0.001) as risk for death to the use of systemic steroids, as well as the use of invasive mechanical ventilation (OR: 2.26; 95% CI: 1.80-2.82; p < 0.001). The male gender was the most affected with 1051 (65.6%) patients. Mean age was 56 years (± 14).

Conclusions: Corticosteroid use was associated with poor prognosis in patients hospitalized for COVID-19 compared to those receiving standard therapy.

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来源期刊

Cirugia Y Cirujanos 医学-外科

CiteScore

0.90

自引率

20.00%

发文量

207

审稿时长

6-12 weeks

期刊介绍： Cirugía y Cirujanoses exponente del desarrollo académico, científico, médico, quirúrgico y tecnológico en materia de salud en México y en el ámbito internacional. Es una revista bimestral, open access, revisada por pares, que publica en español y en inglés (traducido sin coste para los autores) artículos científicos originales, casos clínicos, artículos de revisión de interés general y cartas al editor. Los artículos se seleccionan y publican siguiendo un riguroso análisis, de acuerdo con los estándares internacionalmente aceptados. Sus espacios están abiertos a los académicos, así como a todo miembro de la comunidad médica que manifieste interés por utilizar este foro para publicar sus trabajos.