骨髓间充质干细胞线粒体移植在器官损伤修复中的研究进展。

IF 2.5 3区医学 Q3 CELL & TISSUE ENGINEERING

Stem cells and development Pub Date : 2023-07-01 DOI:10.1089/scd.2023.0019

Xuezhou Yang, Kaiting Ning, Dong-En Wang, Huiyun Xu

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引用次数: 0

摘要

骨髓间充质干细胞(BMSC)线粒体移植作为一种潜在的器官损伤修复治疗创新已经引起了人们的极大兴趣。以往的研究主要集中在其转移途径和治疗作用上。然而，其内在机制尚未被很好地破译。需要对目前的研究现状进行总结，以明确未来的研究方向。因此，我们对近年来BMSC线粒体移植在器官损伤修复中的应用进展进行综述。总结了其迁移途径和效应，并对今后的研究方向提出了建议。

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Progress of Bone Marrow Mesenchymal Stem Cell Mitochondrial Transfer in Organ Injury Repair.

There has been an upsurge of interest in the bone marrow mesenchymal stem cell (BMSC) mitochondrial transfer as a potential therapeutic innovation in organ injury repair. Previous research mainly focused on its transfer routes and therapeutic effects. However, its intrinsic mechanism has not been well deciphered. The current research status needs to be summarized for the clarification of future research direction. Therefore, we review the recent significant progress in the application of BMSC mitochondrial transfer in organ injury repair. The transfer routes and effects are summarized, and some suggestions on the future research direction are provided.

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来源期刊

Stem cells and development 医学-细胞与组织工程

CiteScore

7.80

自引率

2.50%

发文量

审稿时长

3 months

期刊介绍： Stem Cells and Development is globally recognized as the trusted source for critical, even controversial coverage of emerging hypotheses and novel findings. With a focus on stem cells of all tissue types and their potential therapeutic applications, the Journal provides clinical, basic, and translational scientists with cutting-edge research and findings. Stem Cells and Development coverage includes: Embryogenesis and adult counterparts of this process Physical processes linking stem cells, primary cell function, and structural development Hypotheses exploring the relationship between genotype and phenotype Development of vasculature, CNS, and other germ layer development and defects Pluripotentiality of embryonic and somatic stem cells The role of genetic and epigenetic factors in development