肾脏替代疗法对巯嘌呤中毒患者的影响：是时候修订指南了

IF 16.4 1区化学 Q1 CHEMISTRY, MULTIDISCIPLINARY

Accounts of Chemical Research Pub Date : 2024-01-01 DOI:10.2174/1574886318666230714105801

H J L Quaedvlieg, F N Polderman, M Borkent, De H J M Jonge, P A Annema, L J J Derijks, M A Sikma, C Bethlehem

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引用次数: 0

摘要

简介巯嘌呤是一种硫嘌呤类药物，用于治疗各种免疫调节紊乱，如自身免疫性肝炎。硫嘌呤代谢过程复杂，有用药过量的风险，尤其是当肝功能障碍导致代谢受损时。肝中毒可能是由于巯嘌呤用药过量所致，在及时停药后通常可以逆转：病例介绍：硫嘌呤中毒的治疗主要是支持性治疗，关于通过肾脏替代疗法提高排毒效果的文献不明确：在本例硫嘌呤中毒病例中，一名自身免疫性肝炎患者表现为腹痛、恶心、呕吐和腹泻。本病例报告显示，肾脏替代疗法对巯嘌呤的全身清除率没有影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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The Effect of Renal Replacement Therapy in a Patient with Mercaptopurine Toxicity: Time to Revise Guidelines.

Introduction: Mercaptopurine, a thiopurine, is used in various disorders of immune regulation, such as autoimmune hepatitis. Thiopurine metabolism is complex with risk for overdosing, especially when metabolism is impaired by liver dysfunction. Hepatotoxicity may be due to mercaptopurine overdose and is often reversible after prompt cessation of the drug.

Case presentation: Treatment of thiopurine toxicity is mainly supportive and literature on enhanced elimination by renal replacement therapy is ambiguous.

Conclusion: In this case of thiopurine toxicity, a patient with autoimmune hepatitis presents with abdominal pain, nausea, vomiting, and diarrhea. We show in this case report that renal replacement therapy had no effect on total body clearance of mercaptopurine.

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来源期刊

Accounts of Chemical Research 化学-化学综合

CiteScore

31.40

自引率

1.10%

发文量

312

审稿时长

2 months

期刊介绍： Accounts of Chemical Research presents short, concise and critical articles offering easy-to-read overviews of basic research and applications in all areas of chemistry and biochemistry. These short reviews focus on research from the author’s own laboratory and are designed to teach the reader about a research project. In addition, Accounts of Chemical Research publishes commentaries that give an informed opinion on a current research problem. Special Issues online are devoted to a single topic of unusual activity and significance. Accounts of Chemical Research replaces the traditional article abstract with an article "Conspectus." These entries synopsize the research affording the reader a closer look at the content and significance of an article. Through this provision of a more detailed description of the article contents, the Conspectus enhances the article's discoverability by search engines and the exposure for the research.