胃肠道粘膜肥大细胞定量:病理学家入门指南》。

IF 3.7 3区 医学 Q2 MEDICAL LABORATORY TECHNOLOGY
Robert M Genta, Kevin O Turner, Margaret H Collins, Joshua B Wechsler, Nicoleta C Arva, Maria A Pletneva, Evan S Dellon, Marjorie M Walker
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引用次数: 0

摘要

内涵肥大细胞是免疫系统的重要组成部分,在包括肥大细胞性小肠结肠炎和嗜酸性粒细胞性胃肠疾病在内的多种消化系统疾病中发挥着重要的致病作用。病理学家很少被要求评估胃肠道(GI)活检标本中肥大细胞的分布和密度。然而,由于人们越来越意识到肥大细胞在功能性消化道疾病以及食管和非食管嗜酸性胃肠疾病中的作用,这种要求正变得越来越普遍:为病理学家提供将肥大细胞评估纳入食管、胃和肠道标本评估的工具,制定肥大细胞评估、计数和报告的系统方法:本研究包括文献综述,然后召开多次共识会议,以决定在何处计数肥大细胞以及何为可计数肥大细胞:我们查阅了 135 篇关于消化道肥大细胞含量的论文,选出了 21 篇详细介绍了细胞计数方法(显微镜镜头、高倍视野面积、评估位置、可计数细胞类型)的论文,并将其数据汇总成表。然后,我们从可接受的文献和自身丰富的经验中,就以下方面达成了初步共识:(1) 胃肠道不同部分的正常数量;(2) 可计数肥大细胞的形态;(3) 计数肥大细胞的位置和策略:结论:这是一套关于肥大细胞计数、其分布和位置的报告建议,临床医生可以理解并用于管理决策。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Quantification of Mucosal Mast Cells in the Gastrointestinal Tract: A Primer for Practicing Pathologists.

Context.—: Mast cells are essential components of the immune system and play crucial pathogenetic roles in several digestive diseases, including mastocytic enterocolitis and eosinophilic gastrointestinal disorders. Pathologists have rarely been asked to evaluate the distribution and density of mast cells in gastrointestinal (GI) biopsy specimens. However, such requests are becoming more common because of an increasing awareness of the role of mast cells in functional GI disease and in both esophageal and nonesophageal eosinophilic gastrointestinal disorders.

Objective.—: To provide pathologists with tools to incorporate the assessment of mast cells in the evaluation of esophageal, gastric, and intestinal specimens by developing a systematic approach to their evaluation, counting, and reporting.

Design.—: This study consisted of a review of the literature followed by multiple consensus sessions to decide where to count mast cells and what a countable mast cell is.

Results.—: We reviewed 135 papers addressing the content of mast cells in the digestive tract, selected 21 that detailed how cells were counted (microscope lens, area of high-power fields, locations evaluated, type of cells considered as countable), and summarized their data in a table. Then, drawing from both the acceptable literature and our own extensive experience, we reached a tentative consensus on: (1) the normal numbers in the different segments of the GI tract; (2) the morphology of countable mast cells; and (3) the locations and strategies for counting them.

Conclusions.—: The result is a set of suggestions for reporting mast cell counts, their distribution, and their location in a way clinicians can understand and use for management decisions.

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来源期刊
CiteScore
9.20
自引率
2.20%
发文量
369
审稿时长
3-8 weeks
期刊介绍: Welcome to the website of the Archives of Pathology & Laboratory Medicine (APLM). This monthly, peer-reviewed journal of the College of American Pathologists offers global reach and highest measured readership among pathology journals. Published since 1926, ARCHIVES was voted in 2009 the only pathology journal among the top 100 most influential journals of the past 100 years by the BioMedical and Life Sciences Division of the Special Libraries Association. Online access to the full-text and PDF files of APLM articles is free.
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