用抗体工程战胜病原体。

IF 7.6 2区 工程技术 Q1 CHEMISTRY, APPLIED
Ahlam N Qerqez, Rui P Silva, Jennifer A Maynard
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引用次数: 0

摘要

目前,人们越来越关注找出能预防传染病的抗体,尤其是针对高危人群和尚无疫苗的病原体的抗体。然而,表现为机会性或潜伏性感染的病原体会表达复杂的毒力相关蛋白阵列,并善于躲避免疫反应。一些病原体已经开发出选择性破坏抗体的策略,而另一些病原体则制造诱饵表位,诱使宿主免疫系统产生抗体,这些抗体在最好的情况下没有保护作用,在最坏的情况下会增强致病机理。抗体工程策略可以通过获取保守的中和表位、生成可抵抗捕获或降解的 Fc 结构域,甚至获取隐藏在细胞内的病原体来挫败这些努力。设计抗病原体抗体可以增强保护能力,并指导针对这些复杂病原体的疫苗免疫原的开发。在此,我们将讨论设计抗特定病原体防御机制抗体的一般策略。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Outsmarting Pathogens with Antibody Engineering.

There is growing interest in identifying antibodies that protect against infectious diseases, especially for high-risk individuals and pathogens for which no vaccine is yet available. However, pathogens that manifest as opportunistic or latent infections express complex arrays of virulence-associated proteins and are adept at avoiding immune responses. Some pathogens have developed strategies to selectively destroy antibodies, whereas others create decoy epitopes that trick the host immune system into generating antibodies that are at best nonprotective and at worst enhance pathogenesis. Antibody engineering strategies can thwart these efforts by accessing conserved neutralizing epitopes, generating Fc domains that resist capture or degradation and even accessing pathogens hidden inside cells. Design of pathogen-resistant antibodies can enhance protection and guide development of vaccine immunogens against these complex pathogens. Here, we discuss general strategies for design of antibodies resistant to specific pathogen defense mechanisms.

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来源期刊
Annual review of chemical and biomolecular engineering
Annual review of chemical and biomolecular engineering CHEMISTRY, APPLIED-ENGINEERING, CHEMICAL
CiteScore
16.00
自引率
0.00%
发文量
25
期刊介绍: The Annual Review of Chemical and Biomolecular Engineering aims to provide a perspective on the broad field of chemical (and related) engineering. The journal draws from disciplines as diverse as biology, physics, and engineering, with development of chemical products and processes as the unifying theme.
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