基于干细胞的皮肤再生和伤口愈合药物递送策略:潜在的临床应用。

IF 5 3区 医学 Q2 IMMUNOLOGY
Weiyue Zhang, Xin Huang
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引用次数: 0

摘要

干细胞为基础的治疗被广泛认为是一种有前途的组织再生医学策略。然而,将干细胞应用于皮肤再生和伤口愈合还存在一些障碍,包括确定最佳来源、干细胞的处理和给药方法以及干细胞在伤口部位的存活和功能。由于直接应用干细胞的局限性,本文旨在讨论几种基于干细胞的皮肤再生和伤口愈合药物递送策略及其潜在的临床应用。我们介绍了不同类型的干细胞及其在伤口修复中的作用。此外,基于干细胞的药物传递系统,包括干细胞膜包被纳米颗粒、干细胞来源的细胞外囊泡、干细胞作为药物载体、无支架干细胞片和装载干细胞的支架,在皮肤再生和伤口愈合领域得到了进一步的研究。更重要的是,干细胞膜涂层纳米技术在广泛的生物医学领域与其他药物传递系统相比具有很大的优势。综上所述,基于干细胞的药物递送策略在治疗皮肤再生和伤口愈合方面具有很大的前景。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications.

Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications.

Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications.

Stem cell-based drug delivery strategy for skin regeneration and wound healing: potential clinical applications.

Stem cell-based therapy is widely accepted to be a promising strategy in tissue regenerative medicine. Nevertheless, there are several obstacles to applying stem cells in skin regeneration and wound healing, which includes determining the optimum source, the processing and administration methods of stem cells, and the survival and functions of stem cells in wound sites. Owing to the limitations of applying stem cells directly, this review aims to discuss several stem cell-based drug delivery strategies in skin regeneration and wound healing and their potential clinical applications. We introduced diverse types of stem cells and their roles in wound repair. Moreover, the stem cell-based drug delivery systems including stem cell membrane-coated nanoparticles, stem cell-derived extracellular vesicles, stem cell as drug carriers, scaffold-free stem cell sheets, and stem cell-laden scaffolds were further investigated in the field of skin regeneration and wound healing. More importantly, stem cell membrane-coating nanotechnology confers great advantages compared to other drug delivery systems in a broad field of biomedical contexts. Taken together, the stem cell-based drug delivery strategy holds great promise for treating skin regeneration and wound healing.

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来源期刊
CiteScore
11.10
自引率
1.20%
发文量
45
审稿时长
11 weeks
期刊介绍: Inflammation and Regeneration is the official journal of the Japanese Society of Inflammation and Regeneration (JSIR). This journal provides an open access forum which covers a wide range of scientific topics in the basic and clinical researches on inflammation and regenerative medicine. It also covers investigations of infectious diseases, including COVID-19 and other emerging infectious diseases, which involve the inflammatory responses. Inflammation and Regeneration publishes papers in the following categories: research article, note, rapid communication, case report, review and clinical drug evaluation.
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