Doug A Medvetz, Khadijah M Hindi, Matthew J Panzner, Andrew J Ditto, Yang H Yun, Wiley J Youngs
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引用次数: 119
摘要
一类由4,5-二氯- 1h -咪唑衍生的Ag(I) n -杂环碳银配合物1-3对人卵巢癌OVCAR-3、乳腺癌MB157和宫颈癌Hela细胞的抗癌活性进行了评价。银复合物1-3对卵巢癌和乳腺癌细胞系有活性。一项初步的体内研究表明，1对小鼠卵巢癌有活性。在这些研究中获得的结果证明了这些化合物在体内的进一步研究。
Anticancer Activity of Ag(I) N-Heterocyclic Carbene Complexes Derived from 4,5-Dichloro-1H-Imidazole.
A class of Ag(I) N-heterocyclic carbene silver complexes, 1-3, derived from 4,5-dichloro-1H-imidazole has been evaluated for their anticancer activity against the human cancer cell lines OVCAR-3 (ovarian), MB157 (breast), and Hela (cervical). Silver complexes 1-3 are active against the ovarian and breast cancer cell lines. A preliminary in vivo study shows 1 to be active against ovarian cancer in mice. The results obtained in these studies warrant further investigation of these compounds in vivo.
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