旋花叶对中枢神经系统抑制和抗焦虑活性的评价。

Q3 Psychology
Sumayya Khan, Chandra Kala, Manoj Goyal, S K Yadav, Mohamad Taleuzzaman
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引用次数: 0

摘要

背景:旋花(Convolvulus pluricaulis)是一种本土植物,在阿育吠陀中通常被称为Rasayana,主要被推荐用于精神刺激和恢复活力的治疗。旋花被用作健脑药。据报道,这种植物是一种显著的改善记忆的药物。它被用作精神兴奋剂和镇静剂。据报道,它可以减少精神紧张。目的:探讨旋花叶水酒精提取物对小鼠中枢神经系统的保护作用及抗焦虑作用。方法:在索氏装置中,用水和酒精混合溶液对旋花叶的提取物进行顺序分离。一项急性毒性研究是按照经合组织的指导方针进行的。实验采用1、10、100、500、1000、2000 mg/kg不同剂量的旋花水醇提取物对18只白化雄性小鼠进行14 d的毒性评价。以100、200、300 mg/kg剂量的旋花叶水酒精提取物为实验对象,采用光敏计、空地、转杆、握力、高架加迷宫、孔板、斜面、烟囱等实验对小鼠的精神运动活性进行了研究。结果:旋花叶水醇提取物急性毒性试验为4类。因此,选择100、200和300 mg/kg剂量的旋花叶水酒精提取物进行进一步的药理研究。试验剂量100、200、300的小鼠精神运动测试(视压计、开阔场地、旋转杆、握力、孔板、斜面、烟囱、高架加迷宫、光暗模型)结果显示中枢神经系统抑制和抗焦虑作用。结论:旋花叶水酒精提取物在100、200、300 mg/kg剂量下对小鼠具有中枢神经系统抑制和抗焦虑作用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Evaluation of CNS Depressant and Anti-anxiety Activities of Leaves of Convolvulus pluricaulis.

Background: Convolvulus pluricaulis is a native plant that is commonly mentioned in Ayurveda as a Rasayana and is primarily recommended for use in mental stimulation and rejuvenation therapy. Convolvulus pluricaulis is used as a brain tonic. The plant is reported to be a prominent memory-improving drug. It is used as a psychostimulant and tranquilizer. It is reported to reduce mental tension.

Objective: The present study aimed to explore the protective effect of hydroalcoholic extract from the leaves of Convolvulus pluricaulis along with CNS depressant and anti-anxiety activities, in models of mice.

Methods: The extract from leaves of Convolvulus pluricaulis were sequentially isolated with a mixture of water and alcohol solution in the soxhlet apparatus. An acute toxicity study was conducted as per OECD guidelines no. 423, in which 18 Albino male mice were treated with different doses (1, 10, 100, 500, 1000, and 2000 mg/kg) of hydroalcoholic extract of Convolvulus pluricaulis and assessed for toxicity parameters for 14 days. Various psychomotor activities of hydroalcoholic extract from leaves of Convolvulus pluricaulis for 100, 200, and 300 mg/kg doses were performed in mice by using various tests like actophotometer, open field, rota-rod, grip strength tests, elevated plus maze, hole board test, inclined plane, chimney test.

Results: The hydroalcoholic extract from leaves of Convolvulus pluricaulis was found to fall under category 4 in the acute toxicity study. Therefore, 100, 200, and 300 mg/kg doses of hydroalcoholic extract of leaves of Convolvulus pluricaulis were selected for the further pharmacological study. The results of psychomotor tests (actophotometer, open field, rota-rod, grip strength, hole board test, inclined plane, chimney test, elevated plus maze, light-dark model) for test doses 100, 200, and 300 in mice showed CNS depressant and anti-anxiety effects.

Conclusion: Hydroalcoholic extract from leaves of Convolvulus pluricaulis at the 100, 200, and 300 mg/kg doses has shown CNS depressant and anti-anxiety effects in mice models.

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来源期刊
Central nervous system agents in medicinal chemistry
Central nervous system agents in medicinal chemistry Psychology-Neuropsychology and Physiological Psychology
CiteScore
2.10
自引率
0.00%
发文量
21
期刊介绍: Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.
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