Sumayya Khan, Chandra Kala, Manoj Goyal, S K Yadav, Mohamad Taleuzzaman
{"title":"旋花叶对中枢神经系统抑制和抗焦虑活性的评价。","authors":"Sumayya Khan, Chandra Kala, Manoj Goyal, S K Yadav, Mohamad Taleuzzaman","doi":"10.2174/1871524923666230220144640","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong><i>Convolvulus pluricaulis</i> is a native plant that is commonly mentioned in Ayurveda as a Rasayana and is primarily recommended for use in mental stimulation and rejuvenation therapy. <i>Convolvulus pluricaulis</i> is used as a brain tonic. The plant is reported to be a prominent memory-improving drug. It is used as a psychostimulant and tranquilizer. It is reported to reduce mental tension.</p><p><strong>Objective: </strong>The present study aimed to explore the protective effect of hydroalcoholic extract from the leaves of <i>Convolvulus pluricaulis</i> along with CNS depressant and anti-anxiety activities, in models of mice.</p><p><strong>Methods: </strong>The extract from leaves of <i>Convolvulus pluricaulis</i> were sequentially isolated with a mixture of water and alcohol solution in the soxhlet apparatus. An acute toxicity study was conducted as per OECD guidelines no. 423, in which 18 Albino male mice were treated with different doses (1, 10, 100, 500, 1000, and 2000 mg/kg) of hydroalcoholic extract of <i>Convolvulus pluricaulis</i> and assessed for toxicity parameters for 14 days. Various psychomotor activities of hydroalcoholic extract from leaves of <i>Convolvulus pluricaulis</i> for 100, 200, and 300 mg/kg doses were performed in mice by using various tests like actophotometer, open field, rota-rod, grip strength tests, elevated plus maze, hole board test, inclined plane, chimney test.</p><p><strong>Results: </strong>The hydroalcoholic extract from leaves of <i>Convolvulus pluricaulis</i> was found to fall under category 4 in the acute toxicity study. Therefore, 100, 200, and 300 mg/kg doses of hydroalcoholic extract of leaves of <i>Convolvulus pluricaulis</i> were selected for the further pharmacological study. The results of psychomotor tests (actophotometer, open field, rota-rod, grip strength, hole board test, inclined plane, chimney test, elevated plus maze, light-dark model) for test doses 100, 200, and 300 in mice showed CNS depressant and anti-anxiety effects.</p><p><strong>Conclusion: </strong>Hydroalcoholic extract from leaves of <i>Convolvulus pluricaulis</i> at the 100, 200, and 300 mg/kg doses has shown CNS depressant and anti-anxiety effects in mice models.</p>","PeriodicalId":9799,"journal":{"name":"Central nervous system agents in medicinal chemistry","volume":null,"pages":null},"PeriodicalIF":0.0000,"publicationDate":"2023-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Evaluation of CNS Depressant and Anti-anxiety Activities of Leaves of <i>Convolvulus pluricaulis</i>.\",\"authors\":\"Sumayya Khan, Chandra Kala, Manoj Goyal, S K Yadav, Mohamad Taleuzzaman\",\"doi\":\"10.2174/1871524923666230220144640\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><strong>Background: </strong><i>Convolvulus pluricaulis</i> is a native plant that is commonly mentioned in Ayurveda as a Rasayana and is primarily recommended for use in mental stimulation and rejuvenation therapy. <i>Convolvulus pluricaulis</i> is used as a brain tonic. The plant is reported to be a prominent memory-improving drug. It is used as a psychostimulant and tranquilizer. It is reported to reduce mental tension.</p><p><strong>Objective: </strong>The present study aimed to explore the protective effect of hydroalcoholic extract from the leaves of <i>Convolvulus pluricaulis</i> along with CNS depressant and anti-anxiety activities, in models of mice.</p><p><strong>Methods: </strong>The extract from leaves of <i>Convolvulus pluricaulis</i> were sequentially isolated with a mixture of water and alcohol solution in the soxhlet apparatus. An acute toxicity study was conducted as per OECD guidelines no. 423, in which 18 Albino male mice were treated with different doses (1, 10, 100, 500, 1000, and 2000 mg/kg) of hydroalcoholic extract of <i>Convolvulus pluricaulis</i> and assessed for toxicity parameters for 14 days. Various psychomotor activities of hydroalcoholic extract from leaves of <i>Convolvulus pluricaulis</i> for 100, 200, and 300 mg/kg doses were performed in mice by using various tests like actophotometer, open field, rota-rod, grip strength tests, elevated plus maze, hole board test, inclined plane, chimney test.</p><p><strong>Results: </strong>The hydroalcoholic extract from leaves of <i>Convolvulus pluricaulis</i> was found to fall under category 4 in the acute toxicity study. Therefore, 100, 200, and 300 mg/kg doses of hydroalcoholic extract of leaves of <i>Convolvulus pluricaulis</i> were selected for the further pharmacological study. The results of psychomotor tests (actophotometer, open field, rota-rod, grip strength, hole board test, inclined plane, chimney test, elevated plus maze, light-dark model) for test doses 100, 200, and 300 in mice showed CNS depressant and anti-anxiety effects.</p><p><strong>Conclusion: </strong>Hydroalcoholic extract from leaves of <i>Convolvulus pluricaulis</i> at the 100, 200, and 300 mg/kg doses has shown CNS depressant and anti-anxiety effects in mice models.</p>\",\"PeriodicalId\":9799,\"journal\":{\"name\":\"Central nervous system agents in medicinal chemistry\",\"volume\":null,\"pages\":null},\"PeriodicalIF\":0.0000,\"publicationDate\":\"2023-01-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Central nervous system agents in medicinal chemistry\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.2174/1871524923666230220144640\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q3\",\"JCRName\":\"Psychology\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Central nervous system agents in medicinal chemistry","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.2174/1871524923666230220144640","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"Psychology","Score":null,"Total":0}
Evaluation of CNS Depressant and Anti-anxiety Activities of Leaves of Convolvulus pluricaulis.
Background: Convolvulus pluricaulis is a native plant that is commonly mentioned in Ayurveda as a Rasayana and is primarily recommended for use in mental stimulation and rejuvenation therapy. Convolvulus pluricaulis is used as a brain tonic. The plant is reported to be a prominent memory-improving drug. It is used as a psychostimulant and tranquilizer. It is reported to reduce mental tension.
Objective: The present study aimed to explore the protective effect of hydroalcoholic extract from the leaves of Convolvulus pluricaulis along with CNS depressant and anti-anxiety activities, in models of mice.
Methods: The extract from leaves of Convolvulus pluricaulis were sequentially isolated with a mixture of water and alcohol solution in the soxhlet apparatus. An acute toxicity study was conducted as per OECD guidelines no. 423, in which 18 Albino male mice were treated with different doses (1, 10, 100, 500, 1000, and 2000 mg/kg) of hydroalcoholic extract of Convolvulus pluricaulis and assessed for toxicity parameters for 14 days. Various psychomotor activities of hydroalcoholic extract from leaves of Convolvulus pluricaulis for 100, 200, and 300 mg/kg doses were performed in mice by using various tests like actophotometer, open field, rota-rod, grip strength tests, elevated plus maze, hole board test, inclined plane, chimney test.
Results: The hydroalcoholic extract from leaves of Convolvulus pluricaulis was found to fall under category 4 in the acute toxicity study. Therefore, 100, 200, and 300 mg/kg doses of hydroalcoholic extract of leaves of Convolvulus pluricaulis were selected for the further pharmacological study. The results of psychomotor tests (actophotometer, open field, rota-rod, grip strength, hole board test, inclined plane, chimney test, elevated plus maze, light-dark model) for test doses 100, 200, and 300 in mice showed CNS depressant and anti-anxiety effects.
Conclusion: Hydroalcoholic extract from leaves of Convolvulus pluricaulis at the 100, 200, and 300 mg/kg doses has shown CNS depressant and anti-anxiety effects in mice models.
期刊介绍:
Central Nervous System Agents in Medicinal Chemistry aims to cover all the latest and outstanding developments in medicinal chemistry and rational drug design for the discovery of new central nervous system agents. Containing a series of timely in-depth reviews written by leaders in the field covering a range of current topics, Central Nervous System Agents in Medicinal Chemistry is an essential journal for every medicinal chemist who wishes to be kept informed and up-to-date with the latest and most important developments in the field.